PAUL, WSHARMA, CP2017-03-102017-03-101995174 ,1;224-22910.1006/jcis.1995.1385https://dspace.sctimst.ac.in/handle/123456789/10077An improved solid-support, affinity immunoadsorbent suitable for extracorporeal perfusion of plasma is reported. This consists of hydroxyapatite microspheres coated with a thin layer of poly(vinyl alcohol) and immobilized phenylalanine as ligand. This adsorbent can remove IgG immunoglobulins specifically from plasma. The modified adsorbent may be used for direct hemoperfusion as a cheaper alternative to plasma adsorption therapy by eliminating cell separator for selective removal of antibodies belonging to immunoglobulin G class. (C) 1995 Academic Press, Inc.Chemistry