SHIVAKUMAR, K2017-03-102017-03-10199568 ,12;1221-1226https://dspace.sctimst.ac.in/handle/123456789/10018Magnesium plays an important role in maintaining the structural and functional integrity of the cardiovascular system. Its influence on cardiac ion channels has immense clinical implications and is the subject of several incisive investigations. Magnesium deficiency may lead to a wide spectrum of vascular and cardiac complications. This article reviews evidence that magnesium deficiency promotes hypercoagulability of blood, atherogenesis, vasoconstriction, cardiac arrhythmias and cardiac muscle damage. Mechanisms underlying these effects are briefly discussed. Further, it is proposed that the myocardial lesions of chronic magnesium deficiency may result from recurrent episodes of mild ischaemia and reperfusion and consequent free-radical generation.Science & Technology - Other Topics