Sreenivasan, K.2012-12-042012-12-042006JOURNAL OF MOLECULAR RECOGNITION. 19; 5; 408-412http://dx.doi.org/10.1002/jmr.797http://onlinelibrary.wiley.com/doi/10.1002/jmr.797/abstracthttps://dspace.sctimst.ac.in/handle/123456789/334The surface of polystyrene (PS) was chemically modified by coating a thin layer of polyaniline (PANI) by oxidizing aniline using ammonium persulfate. Affinity sites for creatinine, a clinically relevant molecule, were created in the coated layer by adding creatinine as print molecules during the oxidation. The imprinted layer adsorbed creatinine was compared to non-imprinted surface reflecting the creation of creatinine-specific sites on the surface. The equilibrium was attained rapidly, indicating that a material of this kind is suitable for sensing applications. The adsorbed creatinine on the surface was detected using the technique of Fourier transform attenuated total internal reflection infra red spectroscopy (FT-ATR-IR). The results show that molecularly imprinted surface can enrich molecules of interest and the enriched molecules can be detected using FT-IR. Copyright (c) 2006 John Wiley & Sons, Ltd.Laboratory Diagnosis