Radhakrishnan, AshalathaRadhakrishnan, KurupathRadhakrishnan, Venkataraman V.Mary, Paramban R.Kesavadas, ChandrasekharanAlexander, AleySarma, P. Sankara2012-12-042012-12-042007EPILEPSY RESEARCH. 74; 40942; 81-90http://dx.doi.org/10.1016/j.eplepsyres.2007.01.003http://www.ncbi.nlm.nih.gov/pubmed/17336043https://dspace.sctimst.ac.in/handle/123456789/299Purpose: To investigate the etectro-clinical significance of premature accumulation of corpora amylacea (CoA) in the resected hippocampus of patients with medically refractory mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS).Methods: We compared the clinical and EEG characteristics, and post-operative seizure outcome of 373 (mean age 29.4 years, range 7-55 years) surgically treated MTLE-HS patients with (MTLE-HS-CoA(+), n = 129 [34.5%]) and without. (MTLE-HS-CoA(-), n = 244 [65.5%]) CoA.Results: Age at surgery was significantly higher and duration of epilepsy before surgery was significantly longer for MTLE-HS-CoA(+) patients compared to MTLE-HS-CoA(-) patients. Although the distribution of interictal epileptiform EEG abnormalities did not differ, type 1 ictal EEG pattern was more frequent in MTLE-HS-CoA(+) patients. Among the 21 patients with major interictal psychosis detected prior to epilepsy surgery, 19 (90.5%) belonged to MTLE-HS-CoA(+) group. Schizophrenia-like psychosis was most. prevalent. The post-operative seizure-free outcome was comparable, but significantly more MTLE-HS-CoA(-) patients were free of antiepileptic drugs.Conclusions: Overall, our observations support the hypothesis that the pathological process in MTLE-HS is progressive. MTLE-HS-CoA(+) patients are predisposed to increased psychiatric morbidity. In vivo detection of hippocampal CoA accumulation in the future will help us to understand the neurobiological significance of this phenomenon. (C) 2007 Elsevier B.V. All rights reserved.Neurology