JAMALUDDIN, MKRISHNAN, LK2017-03-102017-03-10199015 ,4;389-39610.1007/BF02702680https://dspace.sctimst.ac.in/handle/123456789/9240Modulations of initial rate kinetics of ADP-induced aggregation of citrated calf platelet-rich plasma by adenosine and ATP were investigated employing a spectrophotometric platelet aggregation assay. The data were analysed according to the tenets of the sequential shape-change and interaction model of aggregation. Adenosine and ATP increased the slopes and intercepts of double-reciprocal plots of ADP-aggregation kinetics. Examination of their slope and intercept effects together with their effects individually and in combination, on aggregation rates, suggested that adenosine and ATP acted at multiple, nonoverlapping, sites.Life Sciences & Biomedicine - Other Topics