JAMALUDDIN, M2017-03-102017-03-10199161 ,8;526-533https://dspace.sctimst.ac.in/handle/123456789/10134Aggregation of blood platelets is indispensable for haemostasis but fraught, in some circumstances, with pathological consequences whose mechanism-based prevention and treatment are a long-sought-after goal that remains elusive partly because of a lack of understanding of mechanisms. A glimmer of new insight is emerging. Aggregation appears to involve stimulus-induced, energy-dependent creation of heterogeneous platelet species which sort out partners by long-range, possibly hydrophobic, attractive forces and cell-adhesion receptor counter-receptor discriminating reactions. Dynamic extrusion of pseudopods with reactive cell-adhesion receptors on them appears to be essential. Aggregation is first order and occurs without significant compression or interdigitation of glycocalyces and cooperativity forms an important aspect of its modulation. Platelets could form a convenient model system to study intercellular interactions.Science & Technology - Other Topics