Shivakumar, K2012-12-042012-12-042002MAGNESIUM RESEARCH. 15; 40972; 307-315http://www.ncbi.nlm.nih.gov/pubmed/12635886https://dspace.sctimst.ac.in/handle/123456789/935Magnesium deficiency is known to produce cardiovascular injury. A large body of experimental evidence supports the postulation that an immuno-inflammatory reaction and increased oxidative stress may damage the myocardium and vasculature in magnesium deficiency. Reparative/reactive fibrosis in response to the injury has, however, received little attention. Recent evidence from a rodent model of acute magnesium deficiency suggests that humoral factors may activate cardiac fibroblasts by a free radical-mediated mechanism and contribute to cardiac fibrogenesis. A similar mechanism may also promote cellular hyperplasia and increased matrix synthesis in the vasculature.Cardiology