Sumi, MGMathai, ASheela, RRadhakrishnan, NSRadhakrishnan, VVIndhulekshmy, RMundayoor, S2012-12-042012-12-042001CLINICAL NEUROPATHOLOGY. 20; 4; 176-180http://www.ncbi.nlm.nih.gov/pubmed/11495007https://dspace.sctimst.ac.in/handle/123456789/362In an attempt to establish a tuberculous etiology, polymerase chain reaction (PCR) and immunohistochemical (IHC) methods were undertaken in formalin-fixed paraffin sections of ten surgical specimens of intracranial tuberculoma. The control group included an equal number of intracranial fungal granuloma. Both PCR and IHC methods did not yield false-positive results in fungal granuloma. PCR was found to be less sensitive (60%) than IHC method (80%) in this study. IHC method definitely possesses several operational advantages over PCR and is more suited to laboratories in developing countries for establishing a tuberculous etiology particularly in those patients in whom the conventional bacteriological methods did not confirm the diagnosis of tuberculoma.Immunology