Browsing by Author "Ajitkumar, V K"

Now showing 1 - 2 of 2
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    An unusual thrombotic complication during percutaneous closure of atrial septal defect.
    (The Journal of invasive cardiology, 2009)
    A case is described where intracardiac thrombus was observed at the junction of the superior vena cava and the right atrium during attempted closure of an atrial septal defect (ASD) using a device similar in design to the Amplatzer septal occluder (Heart R atrial septal occluder). Thrombosis was likely related to the multiple attempts required when deploying the device and the attendant prolonged procedural time. The patient underwent subsequent urgent surgical closure of the ASD.
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    Association of PPARalpha Intron 7 Polymorphism with Coronary Artery Disease: A Cross-Sectional Study.
    (ISRN cardiology, 2011)
    The allelic variants of peroxisome proliferator-activated receptor alpha (PPARalpha) can influence the risk of coronary artery disease (CAD) by virtue of its effect on lipid metabolism. However, the role of PPARalpha intronic polymorphism with CAD has received little attention. The association of allelic variants G/C at intron 7 of the PPAR-alpha gene with CAD was examined in a hospital-based Indian population. PPAR genotyping was performed in 110 male patients with CAD and 120 age and ethnically matched healthy males by PCR amplification of the gene followed by restriction digestion. Presence of C allele showed a positive association with CAD (OR = 2.9; 95% CI [1.65-4.145]; P = .009) and also with dyslipidaemia (OR = 2.95, 95% CI (1.5-4.39); P < .05). Impaired lipid metabolism in carriers of the PPARalpha Intron 7C allele is possibly responsible for the predilection to CAD.