Browsing by Author "Arumugam, S"

Now showing 1 - 4 of 4
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    In vitro and in vivo performance of a dual drug-eluting stent (DDES)
    (BIOMATERIALS, 2010) Huang, YY; Venkatraman, SS; Boey, FYC; Lahti, EM; Umashankar, PR; Mohanty, M; Arumugam, S; Khanolkar, L; Vaishnav, S
    This study reports on a dual drug-eluting stent (DDES) that has an anti-proliferative and an anti-thrombotic in a biodegradable polymer-coated onto a cobalt-chromium stent. The DDES was prepared by spray coating the bare metal stent with a biodegradable polymer loaded with sirolimus and triflusal, to treat against restenosis and thrombosis, respectively. The 2-layered dual-drug coated stent was characterized in vitro for surface properties before and after expansion, as well as for possible delamination by cross-sectioning the stent in vitro. The in vitro anti-platelet behavior of the triflusal-loaded films was investigated by using dynamic platelet adhesion measurements. Additionally, the in vitro degradation and release study of the films and the stents w/single sirolimus and dual sirolimus-triflusal in different formulations were examined. Finally, in vivo studies (in a porcine carotid artery model) were performed for acute thrombosis, inflammation and restenosis at 30 days. The in vitro results show DDES can sustain release both anti-proliferation drug (sirolimus) and anti-thrombosis drug (triflusal), two drugs were controlled in different rates to effectively reduce thrombosis and proliferation at the same time. In vivo results show a significant reduction in restenosis with dual-drug eluting stent compared with the controls (a bare metal stent, a sirolimus coated and a pure polymer-coated stent). The reduction in restenosis with a dual sirolimus-triflusal eluting stent is associated with an inhibition of inflammation, especially thrombus formation, suggesting that such dual-drug eluting stents have a role to play for the treatment of coronary artery disease. (C) 2010 Elsevier Ltd. All rights reserved.
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    Magnetic nanoparticles for liver imaging.
    (Nature India. 2013, 2013-12) Saraswathy, A; Nazeer, SS; Nimi, N; Arumugam, S; Shenoy, SJ; Jayasree, RS
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    Pulsed electromagnetic field therapy results in healing of full thickness articular cartilage defect
    (INTERNATIONAL ORTHOPAEDICS, 2011) Boopalan, PRJVC; Arumugam, S; Livingston, A; Mohanty, M; Chittaranjan, S
    This study aimed to determine the efficacy of PEMF (pulsed electromagnetic field) treatment in experimental osteochondral defect healing in a rabbit model. The study was conducted on 12 New Zealand white rabbits. Six rabbits formed the study group and six rabbits the control group. The right knee joints of all 12 animals were exposed and a 3.5-mm diameter osteochondral defect was created in the trochlear groove. The defect was filled with calcium phosphate scaffold. Six animals from the study group were given PEMF of one hour duration once a day for six weeks with set parameters for frequency of 1 Hz, voltage 20 V, sine wave and current +/- 30 mA. At six weeks the animals were sacrificed and histological evaluation was done using H&E, Safranin O, Maissons trichrome staining and immunohistochemistry for type 2 collagen. The quality of the repair tissue was graded and compared between groups with the Wakitani histological grading scale and a statistical analysis was done. The total histological score was significantly better in the study group (p = 0.002) with regeneration similar to adjacent normal hyaline cartilage. Immunohistochemistry for collagen type II was positive in the study group. PEMF stimulation of osteochondral defects with calcium phosphate scaffold is effective in hyaline cartilage formation. PEMF is a non-invasive and cost effective adjuvant treatment with salvage procedures such as abrasion chondroplasty and subchondral drilling.
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    The Short-Term Effect on Restenosis and Thrombosis of a Cobalt-Chromium Stent Eluting Two Drugs in a Porcine Coronary Artery Model
    (JOURNAL OF INTERVENTIONAL CARDIOLOGY, 2009) Huang, YY; Venkatraman, SS; Boey, FYC; Umashankar, PR; Mohanty, M; Arumugam, S
    (J Interven Cardiol 2009;22:466-478).