Browsing by Author "Dash, GK"

Now showing 1 - 9 of 9
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    Alpha coma evolving into spindle coma in a case of acute fulminant hepatic failure: What does it signify?
    (ANNALS OF INDIAN ACADEMY OF NEUROLOGY, 2010) Das, A; Cherian, A; Dash, GK; Radhakrishnan, A
    A 44-year-old male developed acute fulminant hepatic failure of unknown etiology and expired within four days. His serial electroencephalograms (EEGs) showed diffuse background slowing on day one, which evolved into "alpha coma" and later into "spindle coma" over the ensuing two days. Such EEG transition is hitherto undescribed in patients with hepatic encephalopathy and gives fresh insight into the etiopathogenesis of specific EEG patterns in diffuse encephalopathy.
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    Clinico-radiological spectrum and outcome in idiopathic hypertrophic pachymeningitis
    (JOURNAL OF THE NEUROLOGICAL SCIENCES, 2015) Dash, GK; Thomas, B; Nair, M; Radhakrishnan, A
    Objective: To elucidate the clinico-radiological features, treatment response and outcome of a large cohort of patients (n = 20) with idiopathic hypertrophic pachymeningitis (IHP) and to examine if any of these features could differentiate between IHP and secondary causes of hypertrophic pachymeningitis (SHP). Methods: 20 patients with IHP diagnosed between 1998 and 2009 formed the study cohort. We adopted a validated clinical score to quantitatively assess and document their neurological disability and to compare their pre- and post-treatment outcomes. Appropriate statistical analysis was done to look for any clinical and/or radiological features to differentiate IHP from SHP. Results: Out of the twenty eight consecutive patients with pachymeningitis, 20 were having IHP and 8 were having SHP (Tuberculosis-5, Sarcoidosis-2, Wegener's granulomatosis-1). In IHP, headache and visual symptoms dominated the clinical symptomatology (80% and 75%). In MRI, the peripheral pattern of contrast enhancement was more common with IHP (p = 0.03). The posterior falx and tentorium showing a hypointense center ("fibrosis") and enhancing periphery ("active inflammation") together mimicking "Eiffel-by-night" sign was found to be more commonly associated with IHP (60% vs 12.5%, p = 0.03). Biopsy was done in 9 patients. At a mean follow-up of 51 months (range 24-144 months), the mean pretreatment clinical score improved from 6.55 to 1.80 in 20 patients with IHP (p < 0.001). Conclusions: Our data on the largest cohort of patients with IHP would shed light into its dinico-radiological spectrum, treatment and outcome. The prognosis is satisfactory if managed appropriately. We have highlighted the role of MRI in differentiating between IHP and other causes of SHP. (C) 2015 Published by Elsevier B.V.
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    Garland sign in amyotrophic lateral sclerosis
    (NEUROLOGY INDIA, 2009) Bansal, AR; Dash, GK; Radhakrishnan, A; Kesavadas, C; Nair, M
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    PREDICTORS OF SEIZURE OUTCOME FOLLOWING RESECTIVE SURGERY FOR DRUG RESISTANT EPILEPSY ASSOCIATED WITH FOCAL GLIOSIS
    (EPILEPSIA, 2011) Dash, GK; Rathore, C; Jeyaraj, KM; Radhakrishnan, K
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    RESECTIVE SURGERY FOR DRUG RESISTANT TUMORAL EPILEPSIES: SEIZURE OUTCOME AND ITS PREDICTORS
    (EPILEPSIA, 2013) Dash, GK; Radhakrishnan, A; Kesavadas, C; Abraham, M; Sarma, SP; Radhakrishnan, K
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    Reversible photoparoxysmal response at 1 Hz in a patient with posterior fossa mass lesion
    (NEUROLOGY INDIA, 2010) Dash, GK; Kate, MP; Rathore, C; Radhakrishnan, A
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    Subclinical rhythmic EEG discharge of adults: "SREDA in a child"
    (SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2013) Dash, GK; Sundaran, S; Radhakrishnan, A
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    What Does "Subclinical Rhythmic Electrographic Discharge of Adults" in EEG Signify?
    (JOURNAL OF CLINICAL NEUROPHYSIOLOGY, 2013) Dash, GK; Radhakrishnan, A
    Subclinical rhythmic electrographic discharge of adults (SREDA) is the rarest benign epileptiform variant. It is an established EEG phenomenon that when present may cause confusion with an epileptic discharge for those unfamiliar with the entity. An electronic term search was performed on all EEG reports to identify those records reported as showing SREDA and other benign variants. Serial EEG reports of 5,200 subjects who underwent EEG through our EEG laboratory services between January 2001 and December 2009 were thus scrutinized, and their clinical profile and follow-up data were obtained. A total of four subjects had SREDA (0.07%) in their EEG, and their mean age was 53.7 years. The duration of SREDA ranged from 10 to 60 seconds. SREDA was not associated with any clinical seizures during recording. Two patients remained asymptomatic on long-term follow-up. One patient was found to have idiopathic generalized epilepsy and another patient had Alzheimer disease during the follow-up. Mere presence of SREDA may not have any clinical significance at one point of time. The authors have also highlighted the possible pathophysiological basis of SREDA. Many features of SREDA still remain unresolved: why is it more common in the elderly population, why is its spatial distribution centered over temporoparietal region, why it appears mostly in wakefulness, and what is its pathogenesis? It would be worthwhile if compilation of cases reported world over are performed and further analyzed to reach at a common conclusion on its varied clinical presentations and EEG features.
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