Browsing by Author "Deepa, R"

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    Differential Healing of Full Thickness Rabbit Skin Wound by Fibroblast Loaded Chitosan Sponge
    (JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING, 2013) Deepa, R; Paul, W; Anilkumar, TV; Sharma, CP
    For fabricating skin grafts with differential healing properties, enrichment with biomolecules/cells may be desirable. Earlier, we have developed a biomaterial-quality chitosan for biomedical application. Here we evaluated the wound healing potential of the chitosan-preparation and its variant, prepared by loading homologus fibroblast. Dermal fibroblasts isolated from rabbit skin were seeded on chitosan sponge to fabricate a homologous fibroblast loaded chitosan graft (HFLC). Full thickness excision wounds created on the rabbit dorsum were grafted with these two types of the chitosan sponges; naked or non cellular chitosan graft (NCC) and the homologous fibroblast loaded chitosan graft (HFLC). Post-graft skin-wound samples were examined histomorphologically at 7th, 14th and 21st day for evaluating the nature of the tissue reaction induced by the grafts. The wound healing parameters considered were the extent of re-epithelialisation, collagen deposition and angiogenesis, the thickness of epidermis, number of proliferating cells, vimentin positive cells and alpha smooth muscle actin cells. The results suggested that both the grafts aided wound healing but the HFLC induced a differential pattern of healing at 7 and 14 days featured by enhanced angiogenesis, desmoplasia and a hyperkeratotic dermis. Under therapeutic conditions, the HFLC may be useful for regulating the extent of collagen deposition in the early phases of a healing wound.
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    Urban rural difference in prevalence of self reported diabetes in India – The WHO - ICMR Indian NCD risk factor Surveillance.
    (Diabetes Research and Clinical Practice, 2008) Mohan,V; Mathur, P; Deepa, R; Deepa, M; Shukla, DK; Menon, GR; Anand, K; Desai, NG; Joshi, PP; Mahanta, J; Thankappan, KR; Shah, B
    Recent reports show strikingly high prevalence of diabetes among urban Asian Indians; however, there are very few studies comparing urban, peri-urban and rural prevalence rates of diabetes and their risk factors at the national level. This study is a part of the national non-communicable diseases (NCD) risk factor surveillance conducted in different geographical locations (North, South, East, West/Central) in India between April 2003 and March 2005. A total of 44,523 individuals (age: 15-64 years) inclusive of 15,239 from urban, 15,760 from peri-urban/slum and 13,524 from rural areas were recruited. Major risk factors were studied using modified WHO STEPS approach. Diabetes was diagnosed based on self-reported diabetes diagnosed by a physician. The lowest prevalence of self-reported diabetes was recorded in rural (3.1%) followed by peri-urban/slum (3.2%) and the highest in urban areas (7.3%, odds ratio (OR) for urban areas: 2.48, 95% confidence interval (CI): 2.21-2.79, p<0.001). Urban residents with abdominal obesity and sedentary activity had the highest prevalence of self-reported diabetes (11.3%) while rural residents without abdominal obesity performing vigorous activity had the lowest prevalence (0.7%). In conclusion, this nation-wide NCD risk factor surveillance study shows that the prevalence of self-reported diabetes is higher in urban, intermediate in peri-urban and lowest in rural areas. Urban residence, abdominal obesity and physical inactivity are the risk factors associated with diabetes in this study.
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    Urban rural differences in prevalence of self-reported diabetes in India - The WHO-ICMR Indian NCD risk factor surveillance
    (DIABETES RESEARCH AND CLINICAL PRACTICE, 2008) Mohan, V; Mathur, P; Deepa, R; Deepa, M; Shukla, DK; Menon, GR; Anand, K; Desai, NG; Joshi, PP; Mahanta, J; Thankappan, KR; Shah, B
    Recent reports show strikingly high prevalence of diabetes among urban Asian Indians; however, there are very few studies comparing urban, peri-urban and rural prevalence rates of diabetes and their risk factors at the national level. This study is a part of the national non-communicable diseases (NCD) risk factor surveillance conducted in different geographical locations (North, South, East, West/central) in India between April 2003 and March 2005. A total of 44,523 individuals (age: 15-64 years) inclusive of IS,239 from urban, 15,760 from peri-urban/slum and 13,524 from rural areas were recruited. Major risk factors were studied using modified WHO STEPS approach. Diabetes was diagnosed based on self-reported diabetes diagnosed by a physician. The lowest prevalence of self-reported diabetes was recorded in rural (3.1%) followed by peri-urban/slum (3.2%) and the highest in urban areas (7.3%, odds ratio (OR) for urban areas: 2.48, 95% confidence interval (Cl): 2.21-2.79, p < 0.001). Urban residents with abdominal obesity and sedentary activity had the highest prevalence of self-reported diabetes (11.3%) while rural residents without abdominal obesity performing vigorous activity had the lowest prevalence (0.7%). In conclusion, this nation-wide NCD risk factor surveillance study shows that the prevalence of self-reported diabetes is higher in urban, intermediate in peri-urban and lowest in rural areas. Urban residence, abdominal obesity and physical inactivity are the risk factors associated with diabetes in this study. (c) 2007 Elsevier Ireland Ltd. All rights reserved.