Browsing by Author "George, A"

Now showing 1 - 7 of 7
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    Adaptation of the ACE for a Malayalam speaking population in southern India
    (INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 2004)
    Objective To adapt the Addenbrooke's Cognitive Examination (ACE) as a dementia-screening tool in a community in south India. To establish that items in the adapted version are equivalent to that in the original.Methods The ACE was adapted into the local language, Malayalam (m-ACE), following cultural/linguistic modifications. To establish equivalence, qualitative comparisons were made (on the distribution of scores, percentage scoring at ceiling, and relative difficulty across items) between a UK sample receiving the ACE (n = 50; mean age = 67.9 +/- 7.4; education greater than or equal to9, mean = 10.9 +/- 2.5) and a community-based educationally-stratified Indian sample receiving the m-ACE: 'India greater than or equal to9' (n = 50; mean age = 67.8 +/- 5.2; education greater than or equal to9, mean = 13.9 +/- 2.7) and 'India less than or equal to8' (n = 50; mean age = 67.1 +/- 5.3; education less than or equal to8, mean = 3.1 +/- 2.0).Results Most ACE items were retained. The score distribution (mean +/- ISD), percentage at ceiling, and relative difficulties across items is comparable between the UK and the educationally equivalent India greater than or equal to9 groups. Language, Naming, Attention and Orientation are relatively easy (greater than or equal to80% at ceiling) and Recall and Verbal fluency are relatively difficult (less than or equal to22% at ceiling). Although the percentage at ceiling were lower for the India less than or equal to8 group, the order of relative difficulty was similar and the percentage scoring at floor was less than or equal to10% on all except visuospatial item.Conclusions The m-ACE provides a culture-fair Malayalam adaptation of the ACE with component items of equivalent difficulty. Copyright (C) 2004 John Wiley Sons, Ltd.
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    An instrumental activities of daily living scale for dementia screening in the elderly in developing countries
    (NEUROBIOLOGY OF AGING, 2002) Mathuranath, PS; George, A; Cherian, JP; Alexander, A; Verma, N; Gopinath, N
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    DOES HIPPOCAMPUS PLAY ANY ROLE IN DETERMINING LANGUAGE LATERALIZATION?
    (EPILEPSIA, 2009) Rathore, C; George, A; Sarma, P; Radhakrishnan, K
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    Effects of age, education and gender on verbal fluency
    (JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY, 2003)
    The objective was to study the effects of age, education and gender on verbal fluency in cognitively unimpaired, older individuals. The methods used were as follows: cognitively unimpaired elderly (55-84 years) subjects (n = 153), were administered category (animal) (CF) and letter (/pa/) (LF) fluency tasks, in their native language of Malayalam. Results and conclusions were (1) Level of education, but not age or gender, significantly influence LF. (2) Level of education (directly) and in the elderly subjects, age (inversely) affect CF. (3) Age, but not education, has a differential effect on the tasks of verbal fluency, influencing CF more than LF.
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    Incidence of Alzheimer's disease in India: A 10 years follow-up study
    (Neurol India, 2012-12) Mathuranath, PS; George, A; Ranjith, N; Justus, S; Kumar, MS; Menon, R; Sarma, PS; Verghese, J
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    Instrumental activities of daily living scale for dementia screening in elderly people
    (INTERNATIONAL PSYCHOGERIATRICS, 2005)
    Objective: To develop and validate an Instrumental Activities of Daily Living Scale for elderly people (IADL-E) to use in conjunction with cognitive screening tests for dementia in an educationally and socioculturally heterogeneous population.Method: Eleven IADL items were selected and weighted for major factors causing heterogeneity in the population-gender, education, social (rural/urban) setting and age. Each item was rated for its applicability (yes/no), degree of disability (scored from 0 to 2) and causative impairment (cognitive and/or physical). From this a composite index of cognitive (CDI) or physical (PDI) disability was derived. Validation was performed retrospectively on 240 subjects: 135 without and 105 with dementia by DSM-IV.Results: The IADL-E had a high internal consistency (alpha = 0.95). The area under the receiver operating characteristic (ROC) curve was 0.97 (CI = 0.94-0.99). A cutoff score of 16 on CDI provided a sensitivity of 0.91, specificity 0.99 and positive predictive value 0.76 (at 5% base rate). IADL-E correlated highly with clinical (DSM-IV, K = 0.89), functional (CDR, 0.82) and cognitive (Mini-mental Status Examination, MMSE, 0.74) diagnoses. It showed good responsiveness, with the change on CDI over a median of 23 months correlating significantly with that on MMSE (coefficient =-0.382, CI=-0.667 to -0.098; p=0.009). Individual items had good interrater and test-retest reliability.Conclusions: The IADL-E is a reliable, sensitive and responsive scale of functional abilities useful in dementia screening in a socioculturally heterogeneous population.
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    Subclinical hyperthyroidism and hyperkinetic behavior in children
    (PEDIATRIC NEUROLOGY, 1999)
    The authors report three children who exhibited developmental learning disabilities (DLDs) associated with behavioral disturbances, such as attention deficit, hyperactivity, and autistic features. The thyroid function tests performed as a part of routine endocrinologic evaluation of children with DLDs revealed a hormonal profile consistent with hyperthyroidism, These children had no systemic signs of hyperthyroidism. Treatment with neomercazole resulted in good control of their hyperkinetic behavior and subsequent improvement in language function attributable to an increased attention span, thereby facilitating speech therapy. Although routine screening of all children with DLDs for thyroid dysfunction may not be cost-effective, selective screening of children with familial attention-deficit hyperactivity disorder and those with attention-deficit and hyperactivity in association with DLDs and pervasive developmental disorders appears to be justified. (C) 1999 by Elsevier Science Inc. All rights reserved.