Browsing by Author "Gopinath, N"

Now showing 1 - 4 of 4
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    Age- and height-specific reference limits of blood pressure for Indian children
    (NATIONAL MEDICAL JOURNAL OF INDIA, 1999) Chadha, SL; Vasan, RS; Sarma, PS; Shekhawat, S; Tandon, R; Gopinath, N
    Background. Blood pressure in childhood is the most powerful predictor of hypertension in adults. Norms for blood pressure in children are based on the age- and height-specific distribution of blood pressure in a reference sample of healthy children. Methods, We performed a cross-sectional survey of school children in the age group 5 to 14 years in south Delhi and studied the distribution of systolic and diastolic blood pressure in 8293 children (4623 boys and 3670 girls). Blood pressure was measured in all children with a mercury column sphygmomanometer using a standardized technique. The first and the fourth Korotkoff sounds were taken as indicative of the systolic and the diastolic blood pressure, respectively. Height percentiles were computed for the study sample for every one-year sex-pooled group. Multiple linear regression was then performed for every one-year group in order to estimate the 90th and 95th percentiles of systolic and diastolic blood pressure according to percentiles of height. Results. Age and height, but not gender, emerged as the principal determinants of systolic and diastolic blood pressure in multivariable linear regression analyses. Age- and height-specific 90th and 95th percentile values of systolic and diastolic blood pressure were estimated, which enabled us to categorize children into 'normal', 'high normal' and 'high' blood pressure groups. Conclusions, We present age- and height specific reference values for blood pressure of Indian children based on a large study sample. The use of these standards should aid the identification of children with high blood pressure.
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    An instrumental activities of daily living scale for dementia screening in the elderly in developing countries
    (NEUROBIOLOGY OF AGING, 2002) Mathuranath, PS; George, A; Cherian, JP; Alexander, A; Verma, N; Gopinath, N
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    CHILDREN (10-12 YEARS AGE) OF MOTHERS WITH EPILEPSY HAVE LOWER INTELLIGENCE AND VISUAL ATTENTION
    (EPILEPSIA, 2013) Gopinath, N; Muneer, AK; Unnikrishnan, SK; Thomas, SV
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    Children (10-12 years age) of women with epilepsy have lower intelligence, attention and memory: Observations from a prospective cohort case control study
    (EPILEPSY RESEARCH, 2015) Gopinath, N; Muneer, AK; Unnikrishnan, S; Varma, RP; Thomas, SV
    Objective: To compare the cognitive outcome of children of women with epilepsy (CWE) with matched controls (CWO). Methods: CWE (10-12 years) under follow up in Kerala Registry of Epilepsy and Pregnancy (n= 190) were evaluated with WISC-IV, Trail Making Test (TMT), Rey Auditory Verbal Learning Test (RAVLT) and compared with age and sex matched children of women without epilepsy - CWO (n = 149) drawn from schools in the same region. The dosage was expressed as prescribed daily dose/daily-defined dose (PDD/DDD) ratio in order to make comparisons. Results: The Full Scale IQ of CWE (77.9 +/- 14.6) was 8.5 points lower than that of CWO (86.4 +/- 13.4), which was statistically significant (p=0.001). They performed lower on TMT Part A & B and RAVLT. The FSIQ mean +/- SD; PDD/DDD ratio and number of monotherapy exposure for different anti-epileptic drugs were phenobarbital: (74.5 +/- 14; 1.1 +/- 0.8; 22), valproate: (82.8 +/- 12.4; 0.3 +/- 0.1; 36), carbamazepine: (82.2 +/- 13.9; 0.6 +/- 0.3; 41), phenytoin: (82.6 +/- 13.5; 0.8 +/- 0.3; 11). The FSIQ for those exposed to phenobarbital was significantly (p =0.01) lower than others. The significant predictors of FSIQ differed at lower and higher ends of its spectrum. These predictors were low body mass index and low maternal education for FSIQ < 80 and low maternal education, low maternal IQ and high anti-epileptic drug dosage for FSIQ < 86. High anti-epileptic drug dosage, low maternal IQ and low paternal education were the predictors for FSIQ < 92. Significance: The IQ attention and memory were significantly lower for 10-12 year old CWE when compared to CWO. The important predictors of low FSIQ were antiepileptic drug dosage, maternal IQ and parental education. (C) 2015 Elsevier B.V. All rights reserved.