Browsing by Author "Hingwala, D"

Now showing 1 - 4 of 4
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    Advanced MRI in Rosai-Dorfman disease: Correlation with histopathology
    (JOURNAL OF NEURORADIOLOGY, 2011) Hingwala, D; Neelima, R; Kesavadas, C; Thomas, B; Kapilamoorthy, TR; Radhakrishnan, VV
    Rosai-Dorfman disease is an idiopathic benign lymphoproliferative disorder that can, on rare occasions, cause intracranial or intraspinal lesions with non-specific features on conventional imaging. For this reason, its diagnosis is based on the classical pathological findings of histiocyte proliferation and emperipolesis. In this case report, we describe the imaging features of Rosai-Dorfman disease as visualized by newer types of MRI sequences, such as diffusion tensor imaging (DTI), susceptibility-weighted imaging (SWI) and perfusion-weighted imaging (PWI). In fact, combining the findings of conventional cross-sectional imaging with high fractional anisotropy (FA), a low apparent diffusion coefficient (ADC), mild blooming on SWI and decreased perfusion can help to make the diagnosis of Rosai-Dorfman disease. These newer tools can also be used to clarify the pathology of Rosai-Dorfman disease. (C) 2010 Elsevier Masson SAS. All rights reserved.
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    Correlation between anatomic landmarks and fMRI in detection of the sensorimotor cortex in patients with structural lesions
    (Acta Radiol. 2013, 2013-07) Hingwala, D; Thomas, B; Radhakrishnan, A; Nair, SN; Kesavadas, C
    BACKGROUND: Structural lesions in/near the sensorimotor cortex may cause distortion/obscuration of the anatomic landmarks. PURPOSE: To compare the localization of the sensorimotor cortex using anatomical landmarks and fMRI in the clinical setting in patients with structural lesions in/near the central sulcus. MATERIAL AND METHODS: We analyzed the anatomic and fMRI data of 68 consecutive patients (42 tumors, 15 gliotic lesions, 11 focal cortical dysplasias [FCD]) who underwent MRI to assess the relationship of these lesions to the sensorimotor cortex. Anatomical data was analyzed on conventional two- and three-dimensional sequences. BOLD fMRI was performed with block design hand/leg or lip movement paradigm and general linear model was used for detecting the activated cortex. fMRI was considered as a valid method for identifying the sensorimotor cortex based on previously reported literature. RESULTS: The sensorimotor cortex could not be identified with anatomical landmarks in 9/68 (13.2%) patients. fMRI detected activation in areas different from that predicted by anatomical landmarks in 11/68 (16.2%) cases. This occurred in 5/42 (11.9%) tumors, 6/15 (40%) gliotic lesions, and 0/11 (0%) FCDs. The kappa value for concordance between fMRI and anatomic landmarks was 0.883 overall, 1.0 for tumors, 0.721 for gliotic lesions, and in none of the patients with focal cortical dysplasias. CONCLUSION: In patients with lesions that obscure normal cerebral landmarks, fMRI supplies the information that is not available from the anatomic images. In patients with landmarks that can be recognized, the location of the rolandic cortex may be misjudged in some cases if functional imaging is not used. Anatomic landmarks may not correlate with the area of functional activation in gliotic lesions and tumors. Determining the risk of a postoperative neurologic defect from surgery is likely to be more reliable with functional imaging than with conventional anatomic imaging.
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    LATERALIZING VALUE OF TEMPORAL NEOCORTICAL APPARENT DIFFUSION CO-EFFICIENT (ADC) AND T2 RELAXOMETRY VALUES IN MESIAL TEMPORAL LOBE EPILEPSY WITH HIPPOCAMPAL SCLEROSIS
    (EPILEPSIA, 2013) Hingwala, D; Rathore, C; Jagtap, S; Gautam, N; Abraham, J; Kesavadas, C; Radhakrishnan, K
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    Multimodality imaging of carotid atherosclerotic plaque: Going beyond stenosis
    (Indian J Radiol Imaging., 2013-06) Hingwala, D; Kesavadas, C; Sylaja, PN; Thomas, B; Kapilamoorthy, TR