Browsing by Author "Jacob, A"

Now showing 1 - 5 of 5
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    Emotional facial paresis in temporal lobe epilepsy: its prevalence and lateralizing value
    (SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2003)
    The selection of patients with medically refractory temporal lobe epilepsy (TLE) for surgery depends on the concordance of data from clinical, imaging and electroencephalographic evaluation. Though clinical examination is often normal, emotional facial paresis has been described in patients with TLE. Utilizing a well-characterized group of mesial TLE (MTLE) patients, who have achieved excellent seizure outcome following anterior temporal lobectomy with amygdalohippocampectomy (ATL), we investigated the prevalence, predictive value and associations of emotional facial paresis. When compared to 8 out of 50 control subjects (16%), 36 out of 50 MTLE patients (72%) exhibited unilateral emotional facial paresis; the difference was highly significant (P < 0.0001). The presence of contralateral emotional facial paresis correctly predicted the side of ATL in 86.1% patients. The occurrence of emotional facial paresis was significantly associated with longer duration of epilepsy prior to ATL and left ATL. Our observations confirm that emotional facial parersis contralateral to the side of mesial temporal sclerosis (MTS) is a valuable localizing sign in correctly predicting the epileptogenic temporal lobe. We hypothesize that the presence of an intact right hemisphere and pathological changes more extensive than MTS may be required for emotional facial paresis to readily manifest. (C) 2002 BEA Trading Ltd. Published by Elsevier Science Ltd. All rights reserved.
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    Essential hypertension as a result of neurochemical changes at the rostral ventrolateral medulla
    (JOURNAL OF CLINICAL NEUROSCIENCE, 2013) Thomas, AJ; Gross, BA; Jacob, A; Easwer, E
    Acute ischemia of the brainstem has been known to produce hypertension. After an initial review of central nervous system mechanisms contributing to systemic hypertension and the impact of the rostral ventrolateral medulla (RVLM) on arterial pressure, the authors propose that essential hypertension involves neurochemical changes at the level of the RVLM which are triggered by cerebral ischemia. Experimental and clinical data are presented to show that there is a link between ischemia of the brainstem and chronic hypertension. Atherosclerosis of the cerebral circulation leads to ischemia of the RVLM and other regions with autonomic function. This ischemic process results in increased availability of angiotensin II in the RVLM, which maintains the chronic hypertensive state via either direct stimulation of the RVLM or exacerbation of brainstem ischemia due to increased vasoconstriction. (C) 2013 Elsevier Ltd. All rights reserved.
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    Paroxysmal exercise-induced dystonia with optic atrophy: A-30-year follow-up
    (NEUROLOGY INDIA, 2010) Larner, AJ; Jacob, A
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    Prevalence and localizing value of emotional facial paresis in medically refractory temporal lobe epilepsy.
    (EPILEPSIA, 2005) Cherian, JP; Jacob, A; Radhakrishnan, K; Sarma, SP
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    Two siblings with Allgrove's syndrome and extrapyramidal features
    (NEUROLOGY INDIA, 2003)
    We report two siblings with Allgrove's syndrome and extrapyramidal features. Though various neurological abnormalities have been described in this disorder, we report the first patient of Allgrove's syndrome associated with dystonia and chorea.