Browsing by Author "Jayabalan, M."

Now showing 1 - 2 of 2
  • Item
    Effect of hydroxyapatite on the biodegradation and biomechanical stability of polyester nanocomposites for orthopaedic applications
    (ACTA BIOMATERIALIA, 2010)
    The effect of hydroxyapatite (HAP) on the performance of nanocomposites of an unsaturated polyester, i.e. hydroxy-terminated high molecular weight poly(proplyene fumarate) (HT-PPFhm), was investigated A thermoset nanocomposite was prepared with nanoparticles of calcined HAP (<100 nm, rod-like shape, filler content 30 wt %), HT-PPFhm and N-vinyl pyrrolidone, dibenzoyl peroxide and N,N-dimethyl aniline. Two more nanocomposites were prepared with precipitated HAP nanoparticles (<100 nm rod-like shape) and commercially available HAP nanoparticles (<200 nm spherical shape), respectively Calcined HAP nanoparticles resulted in very good crosslinking in the resin matrix with high crosslinking density and Interfacial bonding with the polymer. owing to the rod-like shape of the nanoparticles, this gave improved biomechanical strength and modulus and also controlled degradation of the nanocomposite for scaffold formation The tissue compatibility and osteocompatibility of the nanocomposite containing calcined HAP nanoparticles was evaluated The tissue compatibility was Studied by Intramuscular implantation in a rabbit animal model for 3 months as per ISO standard 10993/6 The in vivo femoral bone repair was also carried out in the rabbit animal model as per ISO standard 10993/6 The nanocomposite containing calcined HAP nanoparticles is both biocompatible and osteocompatible (C) 2009 Acta Materialia Inc Published by Elsevier Ltd All rights reserved.
  • Item
    Injectable biomaterials for minimally invasive orthopedic treatments
    (JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2009)
    Biodegradable and injectable hydroxy terminated-poly propylene fumarate (HT-PPF) bone cement was developed. The injectable formulation consisting HT-PPF and comonomer, n-vinyl pyrrolidone, calcium phosphate filler, free radical catalyst, accelerator and radiopaque agent sets rapidly to hard mass with low exothermic temperature. The candidate bone cement attains mechanical strength more than the required compressive strength of 5 MPa and compressive modulus 50 MPa. The candidate bone cement resin elicits cell adhesion and cytoplasmic spreading of osteoblast cells. The cured bone cement does not induce intracutaneous irritation and skin sensitization. The candidate bone cement is tissue compatible without eliciting any adverse tissue reactions. The candidate bone cement is osteoconductive and inductive and allow osteointegration and bone remodeling. HT-PPF bone cement is candidate bone cement for minimally invasive radiological procedures for the treatment of bone diseases and spinal compression fractures.