Browsing by Author "KARTHA, CC"

Now showing 1 - 20 of 29
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    A SIMPLIFIED METHOD FOR CULTURE OF HUMAN-FETAL HEART-TISSUE
    (INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY, 1989) NAIR, RR; KARTHA, CC
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    BUMPS ON THE HEAD
    (CURRENT SCIENCE, 1993) KARTHA, CC
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    CELL-ADHESION AND GROWTH ON SYNTHETIC HYDROGEL BEADS
    (BULLETIN OF MATERIALS SCIENCE, 1989) SHIVAKUMAR, K; NAIR, RR; JAYAKRISHNAN, A; KARTHA, CC; VALIATHAN, MS
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    CLINICAL COURSE OF ENDOMYOCARDIAL FIBROSIS
    (BRITISH HEART JOURNAL, 1989)
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    CURRENT CONCEPTS OF ATHEROGENESIS
    (CURRENT SCIENCE, 1992) KARTHA, CC
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    DISCORDANT ATRIOVENTRICULAR CONNECTION AND CONCORDANT VENTRICULOARTERIAL CONNECTION INSITUS INVERSUS - ISOLATED VENTRICULAR NONINVERSION
    (PEDIATRIC CARDIOLOGY, 1991)
    A case of discordant atrioventricular (AV) connection and concordant ventriculoarterial (VA) connection (with aortomitral fibrous continuity and tricuspid pulmonary discontinuity) in situs inversus (I, D, I) is reported because of its rarity. This segmental combination with abnormally related great arteries in the absence of anomalies of venous connections and/or splenic anomalies is extremely rare.
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    ENDOMYOCARDIAL FIBROSIS IS POSSIBLY AN INTERSTITIAL HEART-DISEASE
    (CURRENT SCIENCE, 1993) KARTHA, CC
    To obtain clues to the pathogenesis of endomyocardial fibrosis (EMF), autopsy material from 42 patients and biopsy specimens from 89 patients were studied histologically. When full blown EMF was present in one cardiac ventricle, the contralateral ventricle with either focal lesions or no visible lesions, had interstitial fibrosis associated with increase in interstitial cellularity. It is suggested that EMF may be a reactive and progressive interstitial fibrosis, a result of cardiac fibroblast growth, with or without proliferation and enhanced collagen synthesis.
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    ENDOTHELIN - A NOVEL REGULATORY PEPTIDE
    (CURRENT SCIENCE, 1992) SHIVAKUMAR, K; KARTHA, CC
    Endothelins are a family of structurally related vasoactive peptides synthesized by selected endothelial and epithelial cells. Endothelin is the most potent vasoactive biomolecule known to date. Recent evidences indicate that it is involved in several physiological and pathophysiological events. It will not be too long before the peptide stakes its claim to be the molecule of the decade.
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    ENHANCED CERIUM CONCENTRATION IN MAGNESIUM-DEFICIENT PLANTS
    (CURRENT SCIENCE, 1989) NAIR, RR; GUPTA, PN; VALIATHAN, MS; KARTHA, CC; EAPEN, JT; NAIR, NG
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    EXPRESSION OF PROTOONCOGENES AND MUSCLE-SPECIFIC GENES DURING CARDIAC-HYPERTROPHY AND DEVELOPMENT IN RATS AND HUMANS
    (JOURNAL OF BIOSCIENCES, 1994) BABU, GJ; SELVAMURUGAN, N; KARTHA, CC; RAJAMANICKAM, C
    A regulatory interdependence of expression of proto-oncogenes and muscle specific genes observed in smooth muscle was examined in cardiac muscle during normal development and hypertrophy both in rats and humans. During normal development in rats, myosin light chain 2 expression is very low at prenatal stages, while c-fos expression starts from the early stages of embryonic development. In aorta constricted rats c-fos induction occurs within 30 min whereas myosin light chain 2 expression is sufficiently high only after 3 or 4 days of post operative period. In the case of humans, the expression of myosin light chain 2 as well as c-fos occurs at high levels during embryonic development. Similar results were obtained-with tissue samples obtained from patients with cardiac abnormalities. Induction of the c-fos gene in cultured myocytes by 12-O-tetradecanoylphorbol 13-acetate has no influence on the expression of myosin light chain 2. These studies were extended with studies on c-myc and beta-myosin heavy chain gene expression which revealed a similar pattern of expression as that of c-fos and myosin light chain 2. These results have indicated that the expression of proto-oncogenes in cardiac muscle may be independently regulated from the expression of muscle specific genes.
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    FROM THE ANNALS OF PLAGUE
    (CURRENT SCIENCE, 1994) KARTHA, CC; JEETENDRA, E
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    GEOCHEMICAL BASIS OF TROPICAL ENDOMYOCARDIAL FIBROSIS
    (CURRENT SCIENCE, 1995) EAPEN, JT; SHIVAKUMAR, K; NAIR, RR; KARTHA, CC; VALIATHAN, MS
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    GEOCHEMICAL BASIS OF TROPICAL ENDOMYOCARDIAL FIBROSIS
    (CURRENT SCIENCE, 1994) VALIATHAN, MS; KARTHA, CC; NAIR, RR; SHIVAKUMAR, K; EAPEN, JT
    Endomyocardial fibrosis (EMF) has a marked preference for the tropics and the poor socio-economic class. Tropical soil is rich in minerals such as monazite and the endomyocardial samples of patients with EMF show higher levels of cerium - a major constituent of monazite - in combination with lower concentrations of magnesium. The geochemical hypothesis postulates that poor children are prose to develop magnesium deficiency because of insufficient intake and the higher growth needs for the element. The deficiency of magnesium promotes the absorption of cerium and enhances its toxicity which could form the basis for the initial injury in EMF.
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    INTERACTIONS OF THORIUM AND CERIUM WITH ADENINE-NUCLEOTIDES
    (BIOCHEMISTRY INTERNATIONAL, 1989) SHIVAKUMAR, K; APPUKUTTAN, PS; KARTHA, CC
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    LONG-TERM SOFT-TISSUE RESPONSE TO METALS, CERAMICS AND COMPOSITES - A COMPARATIVE HISTOPATHOLOGICAL EVALUATION
    (BULLETIN OF MATERIALS SCIENCE, 1987) MOHANTY, M; RATHINAM, K; KARTHA, CC
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    PEER-REVIEW UNDER SCRUTINY
    (CURRENT SCIENCE, 1995) KARTHA, CC
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    PROBING THE HEART OF CARDIOMYOPATHIES
    (CURRENT SCIENCE, 1993) KARTHA, CC; SHIVAKUMAR, K
    Current knowledge of aetiopathogenesis of various forms of human cardiomyopathy is reviewed in this article. There are overwhelming evidences to suggest a pathogenetic link between persistent viral infection, induction of autoimmunity (influenced by immune response determinants in the HLA region) and alteration in the differentiated functions of the myocardium in dilated cardiomyopathy. Genetic studies have identified specific defects in patients with hypertrophic cardiomyopathy but the cellular basis of the disease remains unresolved. Endomyocardial diseases associated with hypereosinophilic syndrome and endomyocardial fibrosis of the tropics appear to be two separate entities. A unifying link among endomyocardial fibrosis of diverse causes could be the uniform response of the 'cardiac tissue to injuries of heterogenous nature. Application of microtechniques to endomyocardial biopsy promises definitive information on aetiopathogenesis of cardiomyopathies.