Browsing by Author "Krishnan, KV"

Now showing 1 - 4 of 4
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    CONSTRUCTION OF SKIN TISSUE ON BIODEGRADABLE AND BIOMIMETIC SCAFFOLD USING ADIPOSE-DERIVED MESENCHYMAL STEM CELLS
    (WOUND REPAIR AND REGENERATION, 2014) Krishnan, LK; Sivan, U; Krishnan, KV
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    Reinforcement of amniotic membrane with fibrin coated poly- [Lactide-co-Glycolide-co-Caprolactone] terpolymer containing silver nanoparticles for potential wound healing applications
    (International Journal of Polymeric Materials and Polymeric Biomaterials, 2019-06) Ramakrishnan, R; Krishnan, LK; Nair, RP; Krishnan, KV
    Human amniotic membrane (AM) is reported to possess remarkable therapeutic potential for wound healing due to its inherent bioactive and biocompatible properties. However, poor handling characteristics have limited its clinical use on wounds to a great extent. Reinforcement of AM with a biodegradable polymer is therefore expected to provide adequate mechanical and handling nature. Poly-[Lactide-co-Glycolide-co-Caprolactone] terpolymer incorporated with silver nanoparticles and coated with fibrin is used in this study to reinforce the membrane which delivers bioactive molecules to the wound site without wound contraction. This combination scaffold exhibited desirable properties with excellent biocompatibility for potential use in wound healing applications.
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    Study of visible light activated polymerisation in BISGMA-TEGDMA monomers with Typw 1 and Type 2 photoinitiators using Raman spectroscopy
    (Dental Materials, 2017-01) Vaidyanathan, TK; Vaidyanathan, J; Lizymol, PP; Saraswathy, A; Krishnan, KV
    Objective. The goal of the study was to characterize the efficiency of polymerization of Type 1 and Type 2 initiators for visible light cure of a BisGMA-TEGDMA monomer mixture. Methods. Raman spectroscopy was used to follow conversion during polymerization of a BisGMA-TEGDMA mixture using a Type I photoinitiator diphenyl(2,4,6 dimethylbenzoyl)phosphine oxide (TPO) and a Type II photoinitiator camphorquinone (CQ) and an amine, both initiators at 0.5 wt.%. Different light exposure times and storage times after light curing were used as variables. Results. There was a significant difference between the relative exposure times of TPO and CQ/amine (5 s for TPO vs. 20 s for CQ/Amine) for attaining maximum % conversion (78% in TPO vs. 65% in CQ/Amine). There was also a significant difference in the effect of storage time (no effect in TPO vs. increased % conversion with CQ/Amine). These effects are attributed to differences in the rate controlling steps of free radical generation in Type 1/Type 2 initiators, and the potential for radiative and non-radiative energy losses in CQ/Amine in its excited state. Conclusions. The results confirm that photo-polymerization of BisGMA is much more efficient with TPO than with CQ/amine. Both exposure and storage times were important variables in CQ/amine, but not in TPO. Significance. TPO photolysis generates significantly more free radicals with potentially very little radiative and non-radiative energy loss in comparison with CQ/amine. The resulting improved monomer conversion is of major importance in resisting chemical and mechanical degradation and preventing toxicological adverse effects