Browsing by Author "Kumar, J"

Now showing 1 - 3 of 3
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    Supratentorial Epidermoid Tumors: Evaluation of Management Options and Long-Term Outcome
    (NEUROSURGERY QUARTERLY, 2012) Kesavapisharady, K; Menon, G; Kumar, J; Nair, S
    Epidermoid tumors form nearly 1% of spinal neoplasms and 0.2% to 1.8% of intracranial neoplasms. Intracranial epidermoids are most often located in the cerebellopontine angle, and supratentorial locations are relatively rare. We reviewed our single-institution experience of having treated 32 patients with supratentorial epidermoid tumors with an intention to contribute to the general body of knowledge of these tumors. The clinical profile, imaging characteristics, management options, and long-term outcomes were analyzed retrospectively and compared with the available literature. Supratentorial epidermoids commonly present with seizures closely followed by headache. Diffusion-weighted imaging magnetic resonance imaging is an important imaging tool both in the diagnosis and in the early detection of recurrences. Attempts at total excision can result in serious complications, especially in areas where the capsule is densely adherent to major neurovascular structures. The long-term functional outcome is not influenced by the extent of excision. Surgery should therefore aim at providing maximum tumor clearance without producing any new deficits.
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    Synthesis, characterisation and biocompatibility of surface-functionalised gold nanoparticles
    (JOURNAL OF EXPERIMENTAL NANOSCIENCE, 2012) Raji, V; Kumar, J; Rejiya, CS; Vibin, M; John, A; Abraham, A
    Understanding and controlling the interactions between nanoparticles and living cells are of great importance in the diagnosis and therapeutic applications of nanosized materials. This article describes the synthesis, characterisation and interactions of gold nanoparticles (AuNPs) with different in vitro and in vivo experimental models. Preliminary cytotoxicity studies were carried out in tumour ascites (Dalton's lymphoma ascites and Ehrlich's ascites carcinoma) and normal peritoneal cells for different concentrations and it was found that AuNPs did not cause any cell death or morphological changes even at 100 mu M concentrations. The tissue distribution and toxicity of intravenously administered AuNPs were investigated in mice because of the fundamental importance of obtaining information about the localisation and biocompatibility of this material. Tissue distribution of AuNPs was studied in normal as well as skin tumour-induced Swiss albino mice using inductively coupled plasma-atomic emission spectrophotometer and transmission electron microscopy. Acute cytotoxicity and histopathology were carried out for toxicity evaluation in AuNP-injected normal mice and found that AuNPs did not cause any significant metabolic change. The health and behaviour of animals were normal throughout the study. The biocompatibility assessment of AuNPs both in vitro and in vivo confirmed that triethylene glycol-functionalised AuNPs are compatible to the biological system and can be used as a safe material for various biological applications.
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    Synthesis, characterisation and biocompatibility of surface-functionalized gold nanoparticles
    (Journal of Experimental Nanoscience., 2012) Raji, V; Kumar, J; Rejiya, CS; Vibin, M; John, A; Abraham, A