Browsing by Author "Manju, S"

Now showing 1 - 5 of 5
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    Chitra Acrylosorb Fluid Solidification System ( Project - 8224 )
    (SCTIMST, 2020-07-31) Manju, S; Manoj, Komath; Ajay Prasad, Hrishi
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    Synthesis and evaluation of a hydrogel that binds glucose and releases ciprofloxacin
    (JOURNAL OF MATERIALS SCIENCE, 2010) Manju, S; Antony, M; Sreenivasan, K
    This study reports the formation of a hydrogel generated by polymerizing aminophenyl boronic acid in polyvinyl alcohol (PVA). The gel formed as a result of complexation between the -OH groups of PVA, and boronic acid moieties were stable and exhibited high degree of swelling proportional to the concentration of glucose. Extended swelling was attributed to the strong affinity of the gel to glucose and to the subsequent breaking of the bond formed between PVA and boronic acid groups. Interestingly, the gel was found to bind a high amount of glucose. We evaluated the hydrogel in terms of its ability to bind glucose and to release ciprofloxacin. Retention of antibacterial efficacy of the released drug was also demonstrated. Features such as swelling, drug release, and glucose binding reflect the possibility of tuning a new dressing for wounds particularly in diabetic patients.
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    Targeted coadministration of sparingly soluble paclitaxel and curcumin into cancer cells by surface engineered magnetic nanoparticles
    (JOURNAL OF MATERIALS CHEMISTRY, 2011) Manju, S; Sharma, CP; Sreenivasan, K
    This study presents a feasible method for the fabrication of multifunctional magnetic nanoparticles (MNPs) for the targeted coadministration of two anticancer agents, paclitaxel (PTX) and curcumin (CUR). MNPs were first surface modified with N-[3-(trimethoxysilyl)propyl]ethylenediamine to form a self-assembled monolayer and subsequently conjugated with folic acid and carboxymethylcyclodextrin through amidation between carboxy groups of folic acid/carboxymethylcyclodextrin and amine groups on the nanoparticle surface. Drug release studies showed that PTX/CUR was diffused out from the nanoparticle under low pH, mimicking the intracellular conditions in the lysosome and also at pH 7.4. Cellular viability studies proved the efficacy of the coadministration of PTX/CUR and the dose dependent antiproliferative effect in cancer cell lines (HeLa and glioma cells). The modified nanoparticles were also found to be highly blood compatible indicating their suitability for in vivo applications. In vitro evaluations reflected that owing to the enhanced targeting ability, the newly designed multifunctionalized MNPs can be used as vectors for the coadministration of anticancer agents which may be effective in defending multidrug resistance.