Browsing by Author "Menon, GR"

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    Central Neurocytomas: A Review of an Institutional Series of 33 Cases
    (NEUROSURGERY QUARTERLY, 2012) Menon, GR; Patil, A; Abraham, M; Nair, S
    Objective: Neurocytomas (NCs) comprise a rare but distinct clinicopathologic entity, often with a benign course. Our operative series of 33 patients with NCs attempts to review the clinical characteristics of this rare entity. Method: Retrospective analysis of the case records of all the patients with central NCs operated since January 2000. The following prognostic factors were analyzed for statistical significance: age, sex, location, extent of resection, and the histopathologic grade. Results: The study group included 33 patients with a mean age of 28.87 years (range, 9 to 55 y) and with a male preference (M: F = 20: 13). Increased intracranial headache was the predominant presenting complaint (27/33; 81.8%), followed by gait imbalance, memory deficits, weakness, and seizures. At the first surgery, gross total removal could be achieved only in 16 cases (48.84%). The majority (26/33; 78.78%) were typical NCs and 7 were atypical NCs. Of the 17 patients with residual lesions, only 4 patients showed an increase in the size of the residue and only 2 of them had symptomatic recurrence requiring repeat surgery. Of the 16 patients who underwent radical excision, 4 had recurrence, 1 requiring repeat surgery. Three of the atypical NCs recurred in spite of gross total resection. We had 5 perioperative mortalities, all related to tumor bleeding and postoperative brain swelling. One child with a recurrent fourth ventricular NC expired after adjuvant chemotherapy. Of the remaining 27 patients, 25 patients had a Glasgow outcome score (GOS) of 5 and 2 were in GOS 3 at the end of a mean follow-up period of 4.63 years (range 2 to 11 y). Conclusions: Central NCs are unique tumors of neuronal origin with strong histologic resemblance to other intraventricular tumors of glial origin. NCs are vascular tumors, and their radical removal can be challenging. Although radical surgery is the treatment of choice, they are slow growing, and subtotal resections also provide long-term symptom-free survival even for atypical lesions.
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    Urban rural difference in prevalence of self reported diabetes in India – The WHO - ICMR Indian NCD risk factor Surveillance.
    (Diabetes Research and Clinical Practice, 2008) Mohan,V; Mathur, P; Deepa, R; Deepa, M; Shukla, DK; Menon, GR; Anand, K; Desai, NG; Joshi, PP; Mahanta, J; Thankappan, KR; Shah, B
    Recent reports show strikingly high prevalence of diabetes among urban Asian Indians; however, there are very few studies comparing urban, peri-urban and rural prevalence rates of diabetes and their risk factors at the national level. This study is a part of the national non-communicable diseases (NCD) risk factor surveillance conducted in different geographical locations (North, South, East, West/Central) in India between April 2003 and March 2005. A total of 44,523 individuals (age: 15-64 years) inclusive of 15,239 from urban, 15,760 from peri-urban/slum and 13,524 from rural areas were recruited. Major risk factors were studied using modified WHO STEPS approach. Diabetes was diagnosed based on self-reported diabetes diagnosed by a physician. The lowest prevalence of self-reported diabetes was recorded in rural (3.1%) followed by peri-urban/slum (3.2%) and the highest in urban areas (7.3%, odds ratio (OR) for urban areas: 2.48, 95% confidence interval (CI): 2.21-2.79, p<0.001). Urban residents with abdominal obesity and sedentary activity had the highest prevalence of self-reported diabetes (11.3%) while rural residents without abdominal obesity performing vigorous activity had the lowest prevalence (0.7%). In conclusion, this nation-wide NCD risk factor surveillance study shows that the prevalence of self-reported diabetes is higher in urban, intermediate in peri-urban and lowest in rural areas. Urban residence, abdominal obesity and physical inactivity are the risk factors associated with diabetes in this study.
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    Urban rural differences in prevalence of self-reported diabetes in India - The WHO-ICMR Indian NCD risk factor surveillance
    (DIABETES RESEARCH AND CLINICAL PRACTICE, 2008) Mohan, V; Mathur, P; Deepa, R; Deepa, M; Shukla, DK; Menon, GR; Anand, K; Desai, NG; Joshi, PP; Mahanta, J; Thankappan, KR; Shah, B
    Recent reports show strikingly high prevalence of diabetes among urban Asian Indians; however, there are very few studies comparing urban, peri-urban and rural prevalence rates of diabetes and their risk factors at the national level. This study is a part of the national non-communicable diseases (NCD) risk factor surveillance conducted in different geographical locations (North, South, East, West/central) in India between April 2003 and March 2005. A total of 44,523 individuals (age: 15-64 years) inclusive of IS,239 from urban, 15,760 from peri-urban/slum and 13,524 from rural areas were recruited. Major risk factors were studied using modified WHO STEPS approach. Diabetes was diagnosed based on self-reported diabetes diagnosed by a physician. The lowest prevalence of self-reported diabetes was recorded in rural (3.1%) followed by peri-urban/slum (3.2%) and the highest in urban areas (7.3%, odds ratio (OR) for urban areas: 2.48, 95% confidence interval (Cl): 2.21-2.79, p < 0.001). Urban residents with abdominal obesity and sedentary activity had the highest prevalence of self-reported diabetes (11.3%) while rural residents without abdominal obesity performing vigorous activity had the lowest prevalence (0.7%). In conclusion, this nation-wide NCD risk factor surveillance study shows that the prevalence of self-reported diabetes is higher in urban, intermediate in peri-urban and lowest in rural areas. Urban residence, abdominal obesity and physical inactivity are the risk factors associated with diabetes in this study. (c) 2007 Elsevier Ireland Ltd. All rights reserved.