Browsing by Author "Nair, MK"

Now showing 1 - 3 of 3
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    Guillain-Barre syndrome occurring as a complication of acute nonlymphoblastic leukemia.
    (AMERICAN JOURNAL OF MEDICINE, 1999) Geetha, N; Hussain, BM; Lali, VS; Nair, MK; Kumar, BS
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    Oligodendroglioma : Clinical profile and treatment results
    (NEUROLOGY INDIA, 2002) Jacob, R; Jyothirmayi, R; Dalal, Y; Nambiar, U; Rajan, B; Nair, MK
    Oligodendrogliomas are rare glial tumors with a long natural history. Radical surgery, postoperative radiotherapy, chemotherapy and observation have been suggested as part of primary management. This series reports the presentation and outcome in 34 patients with histologically verified pure oligodendrogliomas treated between 1983 and 1993. All patients were treated at the time of initial diagnosis with surgery, with or without additional radiotherapy. The overall survival and progression free survival rates at five years were 69.8% and 55% respectively. There was no tumor or treatment related factor influencing survival significantly.
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    Ultrastructural analysis of the adjacent epithelium of oral squamous cell carcinoma
    (BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY, 1996) Kannan, S; Kartha, CC; Balaram, P; Chandran, GJ; Pillai, MR; Pillai, KR; Nalinakumari, KR; Nair, MK
    Fifteen biopsies of the immediate adjacent epithelium of oral squamous cell carcinoma mere examined under light and electron microscopy. Light microscopic examination of one micron thick sections revealed that the majority of lesions (67%) had hyperplastic or mildly dysplastic epithelium while the remaining (33%) had moderate to severe dysplasia. Ultrastructural observations showed that all these lesions had subcellular alterations similar to those seen in frank malignant oral tissue, particularly in the lower half of the epithelium. Important ultrastructural changes observed included bizarre nuclei of basal and lower spinal cells, enlarged and multiple nucleoli, presence of interchromatin and perichromatin granules, loss of desmosomes and marked spongiosis as well as disturbed cellular maturation sequences in the keratinocytes evidenced by abnormal and irregular distribution of maturation markers such as keratohyalin granules and tonofilaments. The present study thus shows the value of electron microscopy in the detection of malignant changes in the adjacent epithelium of oral squamous cell carcinoma.