Browsing by Author "Narayan, SK"

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    Fast-wave periodic complexes in a mentally retarded child who later developed subacute sclerosing panencephalitis: a modification of a classic EEG by preexisting brain damage?
    (DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY, 1997) Narayan, SK; Kuruvilla, A; Shanmugam, J; Radhakrishnan, VV
    The EEG of a 12-year-old girl with stage II subacute sclerosing panencephalitis (SSPE), who had also suffered from a non-progressive mental retardation of unknown aetiology since early childhood, revealed periodic generalised stereotyped fast wave bursts synchronous with myoclonic jerks, The background activity was nearly normal, The diagnosis of SSPE was established by raised serum and measles antibody titres, raised CSF IgG, and brain biopsy, This rare type of periodic complex has only once been described in the literature, again in a mentally retarded child who had developed SSPE, We suggest a mechanism of origin of this type of periodic complex drawn from observations in these two cases, anti discuss its significance.
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    Neuro developmental sequelae of pyogenic meningitis in children
    (NEUROLOGY INDIA, 1996) Narayan, SK; Philip, E; Nair, HKC
    97 children above one month of age with pyogenic meningitis were followed up after 6 and 12 months at the child development Center, S.A.T. Hospital, Medical College, Trivandrum. Developmental quotient was obtained using Bayley scale of Infant Development, intelligence quotient using Binet-Kamath test and behavioural assessment by the Eyberg behaviour inventory, The major sequelae observed were mental/developmental retardation 53.2%, behavioural problems 11.3%, focal neurological deficits 7.2%, epilepsy 6.2% and perception deafness 3.1%. Retardation observed in the 4-12 months age group was statistically significantly higher than the 1-3 months age group, Further, mental impairment significantly outweighed motor impairment as a sequel, Acute phase poor responders had high incidence of retardation, 37.5% of those who had focal deficits during acute phasae, continued to have persistent deficit at 12 months follow up.
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    Response to thymectomy in South Indian patients with myasthenia gravis
    (ACTA NEUROLOGICA SCANDINAVICA, 1996)
    Aims - The rate of remission among patients with myasthenia gravis (MG) following thymectomy and the predictors of the outcome have revealed vast variation in studies from different geographic regions raising suspicion about the influence of ethnic factors. Material & methods - We retrospectively evaluated the outcome of 71 South Indian MG patients who were thymectomized between 1987 through 1993 and analyzed the relationship between clinical and histopathological features and postthymectomy outcome. Results - The clinical severity of the disease did not differ between the 29 patients with and 42 patients without a thymoma. Seventynine percent of our patients responded favourably to thymectomy; without additional immunosupression therapy, 52% achieved a near-complete remission. An younger age and milder disease correlated with a good outcome. Patients with thymoma responded as favourably as those without a thymoma. Conclusions - The postthymectomy response of South Indian MG patients in general did not differ from that of Western and Oriental patients.