Browsing by Author "Padmanabhan, V"

Now showing 1 - 3 of 3
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    Neuropsychological impairment and altered thyroid hormone levels in epilepsy
    (NATIONAL MEDICAL JOURNAL OF INDIA, 1998)
    Background. Neuropsychological impairment is a common problem in epilepsy which interferes with the quality of life of patients. Similarly, thyroid hormone levels have been observed to be abnormal in patients with epilepsy on various treatments. This study aimed to ascertain any possible correlation between neuropsychological performance and thyroid hormone levels among epilepsy patients.Methods. Thyroid hormone levels, indices of neuropsychological performance and social adaptation of 43 epilepsy patients were compared with those of age- and sex-matched healthy control subjects.Results. Epilepsy patients exhibited significantly (p<0.001) lower scores on attention, memory, constructional praxis, finger tapping time, and verbal intelligence quotient (IQ) when compared with controls. Their T3, T4 and Free T3 levels were significantly lower; and TSH and Free T4 levels were significantly higher than that of controls. There was no statistically significant correlation between the indices of neuropsychological performance and thyroid hormone levels.Conclusion. We did not observe any correlation between neuropsychological impairment and thyroid hormone levels among patients with epilepsy.
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    Photoluminescence and thermolumineseence properties of tricalcium phosphate phosphors doped with dysprosium and europium
    (BULLETIN OF MATERIALS SCIENCE, 2007) Madhukumar, K; Varma, HK; Komath, M; Elias, TS; Padmanabhan, V; Nair, CMK
    The suitability of calcium phosphate crystals for thermoluminescence dosimetry (TLD) applications is investigated, owing to their equivalence to bone mineral. The alpha and beta phases of tricalcium phosphate (TCP) were synthesized through wet precipitation and high temperature solid state routes and doped with Dy and Eu. The photoluminescence and thermolumineseence studies of the phosphors have been carried out. The TL properties were found to be highly dependent on the method of preparation of the material. Eu doping gave good PL emission, whereas Dy doping was more efficient in TL emission. beta-TCP was found to be less TL sensitive than alpha-TCP, yet it was identified as a better phosphor material owing to its better fading characteristics. The dependence of TL of beta-TCP: Dy on the energy and dose of radiation, and on the doping concentration were studied. The TL intensity was observed to fade exponentially during a storage period of 20 days, but it stabilized at 70% of the initial value after 30 days. The optimum doping concentration was found to be 0.5 mol %.
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    Prevention of hypertension during trans-sphenoidal surgery - The effect of bilateral maxillary nerve block with local anaesthetics
    (ACTA ANAESTHESIOLOGICA SCANDINAVICA, 1997)
    Background: Severe cardiovascular responses are known to occur during trans-sphenoidal excision of the pituitary gland despite adequate depth of anaesthesia. This study was undertaken to evaluate the effects of bilateral maxillary nerve block with local anaesthetics on the cardiovascular responses to various stimuli during this procedure.Methods: In a group of 32 patients, 5-10 mi of a mixture of bupivacaine 0.5% and lignocaine 2% (1:1) was injected in the pterygopalatine fossa after induction of general anaesthesia. Seven control group patients did not receive any nerve block. In all the patients, general anaesthesia was induced with thiopentone and maintained with nitrous oxide-oxygen, pentazocine, boluses of thiopentone and halothane. Pancuronium was used for neuromuscular blockade.Results: In both the groups, maximum hypertension occurred on opening the blades of the bivalve nasal speculum. In the study group, hypertensive response was significantly less following nasal infiltration with adrenaline containing solution (10.26% increase vs. 23.08% in the control group, P<0.05), nasal dissection (2.82% vs. 9.45%, P<0.01) and on application of the nasal speculum (14.93% vs. 35.16%, P<0.01). The effect on heart rate response was not significant.Conclusion: The described technique is a useful adjunct to general anaesthesia for suppressing the haemodynamic responses during trans-sphenoidal surgery.