Browsing by Author "ROUT, D"

Now showing 1 - 9 of 9
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    APPLICATION OF SILVER COLLOIDAL STAINING METHOD IN THE DIAGNOSIS OF INTRACRANIAL GLIOMA
    (INDIAN JOURNAL OF MEDICAL RESEARCH SECTION B-BIOMEDICAL RESEARCH OTHER THAN INFECTIOUS DISEASES, 1993)
    A silver colloidal staining technique for the demonstration of argyrophilic nucleolar organizer regions (Ag-NORs) was used on the paraffin sections of reactive gliosis and grade I astrocytoma tissue. Quantitative as well as qualitative differences of Ag-NORs were found between the cells of reactive gliosis and grade I astrocytoma. In cases of reactive gliosis, the Ag-NOR counts averaged 1.19 +/- 0.16 per nucleus, while in grade I astrocytoma, Ag-NOR counts averaged 2.36 +/- 0.32 per nucleus (P<0.05). Compound Ag-NORs were also seen in the nuclei of cells in grade I astrocytoma while they were not present in the nuclei of cells in cases of reactive gliosis. The results of the study indicate that Ag-NOR technique is an useful method and can be applied in situations where a distinction between grade I astrocytoma and reactive gliosis becomes difficult at the light microscopic level.
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    ARTERIOVENOUS ANEURYSM OF THE OCCIPITAL ARTERY
    (NEURORADIOLOGY, 1993)
    We report an unique case of a giant aneurysm of the occipital artery, with a venous connection to the transverse sinus via an emissary vein. Because of this connection, the term arteriovenous aneurysm is used.
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    CHOROID-PLEXUS PAPILLOMAS
    (BRITISH JOURNAL OF NEUROSURGERY, 1994)
    Choroid plexus papillomas (CPPs) are rare neoplasms accounting for less than 1% of all intracranial tumours. We present our experience with 13 consecutive cases managed by us between 1981 and 1991. There were eight children and five adults. Five patients had tumours in the 4th ventricle, four in lateral ventricle, one in the 3rd ventricle, two in the cerebellomedullary cistern and one in the cerebellopontine angle. The cerebellomedullary cistern is a rare site for CPPs. Although the 4th ventricle remains the common site for adult CPPs, in our series there was a higher incidence of posterior fossa papillomas even in children. Only six patients out of 13 underwent precraniotomy shunts. All patients had their tumours operated upon and verified histologically. Total excision of he tumour could be achieved in nine patients; only a sub total excision was possible in the remaining four. There were two surgical mortalities in the earlier part of this series. Two patients with subtotal excisions underwent radiation therapy; one of these had regrowth of the tumour and another was lost to follow up. The other nine patients are doing well with a follow-up ranging from 9 to 90 months. Surgical resection with the objective of achieving total excision should be attempted in these tumours.
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    CT METRIZAMIDE MYELOGRAPHY IN SYRINGOHYDROMYELIA
    (JOURNAL OF NEURORADIOLOGY, 1987) RAO, VRK; MANDALAM, R; SEOUIERA, R; MOHAN, PK; ROUT, D
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    HISTOPATHOLOGICAL EVALUATION OF POLYMETHYL METHACRYLATE AS AN EMBOLIC AGENT
    (ACTA NEUROCHIRURGICA, 1992)
    Polymethyl methacrylate (PMMA) microspheres were used as an embolic agent to reduce the vascularity in eight patients with intracranial vascular tumours. Post embolization angiograms showed 30-60% reduction in the vascularity of-the tumours. No patient developed any neurological complications in the immediate post-embolization period. These eight patients subsequently underwent surgery for the removal of their tumours. During surgery there was minimal blood loss and a good plane of cleavage was obtained between the tumour and the adjacent brain. The surgical specimens were examined histopathologically for the effects of PMMA. PMMA microspheres, in contrast to other cyano-acrylates-Isobutyl-2-cyanoacrylate (IBCA) - did not elicit either inflammatory reaction or mural angionecrosis within the wall of the embolised vessels. The histopathological studies suggest that PMMA microspheres are an inert material and can be used as an adjunct in the management of intracranial vascular tumours.
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    INTRADURAL SPINAL CAVERNOMAS
    (BRITISH JOURNAL OF NEUROSURGERY, 1992)
    Intradural cavernomas are rare vascular lesions of the spinal cord. Four cases of histologically verified cavernomas of the cord are reported, of which two were extramedullary and two were intramedullary in location. Progressive neurological deficit was the presenting feature in three cases while one patient had a rapid evolution of neurological deficits and was found at surgery to have had bled from the extramedullary lesion. All the patients were subjected to surgery and total excision of the cavernomas was carried out in each case. While two patients improved after surgery the other two remained static. The available literature on spinal cord cavernomas is reviewed.
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    MYCOTIC-ANEURYSMS OF THE INTRACRANIAL VESSELS
    (INDIAN JOURNAL OF MEDICAL RESEARCH, 1994)
    The salient clinical and pathological features are reported of Aspergillus cerebral aneurysms in four young women who had undergone intra-abdominal surgery under spinal anaesthesia and developed clinical features of meningitis 7-16 days postoperatively. The circle of Willis showed ruptured aneurysm in the basilar artery and its branches. The role of iatrogenic factors in the pathogenesis of Asgergillus cerebral aneurysms is highlighted.
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    NUCLEOLAR ORGANIZER REGIONS IN MENINGIOMAS
    (BRITISH JOURNAL OF NEUROSURGERY, 1993)
    Paraffin sections of 305 meningeal tumours were analysed for the presence of nucleolar organizer region (Ag-NOR) in the neoplastic cells, using a one step silver-colloidal staining method. The mean (+/- SEM) Ag-NOR counts were 2.73 +/- 0.21 for atypical and 2.91 +/- 0.18 for papillary variants of meningioma. In meningotheliomatous and transitional variants of meningioma, the mean Ag-NOR counts were 1.41 +/- 0.34 and 1.38 +/- 0.31, respectively. The recurrence rates were significantly higher in atypical meningiomas than in other histopathological variants (p < 0.05). Differences in the mean Ag-NOR numbers between meningothelial and transitional variants in their primary and recurrent tumours were not significantly different (p > 0.05). The results of this study indicates that estimation of Ag-NOPs can be applied in predicting the aggressive clinical behaviour of primary meningeal tumours.
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    SPONTANEOUS HEMORRHAGE IN ACOUSTIC NEURINOMAS
    (BRITISH JOURNAL OF NEUROSURGERY, 1995)
    Gross intratumoural haemorrhage in acoustic neurinoma is rare. The authors describe seven patients, out of a consecutive 99 cases of acoustic neurinoma operated by the first author, who presented with haemorrhage. Risk factors for haemorrhage appear to be large size, mixed Antoni type and secondary vascular changes.