Browsing by Author "Rethikala, PK"

Now showing 1 - 3 of 3
  • Item
    In vitro release study and antimicorbial property evaluation of ofloxacin loaded poly (2-hydroxyethyl methacrylate)/poly (caprolactone)/poly (ethylene glycol) hydrogel system for burn wound management
    (Journal of Drug Delivery and therapeutics, 2017-01) Rethikala, PK; Nair, RP; Krishnan, LK; Krishnan, VK
    Monomer 2-hydroxy ethyl methacrylate containing small amounts of poly(caprolactone) and poly(ethylene glycol) incorporated with an antibiotic ofloxacin was polymerized by photo-polymerization technique using 2,4,6 trimethyl benzoyl diphenyl phosphine oxide (TPO) as photo-initiator. Encapsulation efficiency and in vitro drug release was studied using UV-visible spectroscopy. Swelling analysis was resorted to compare fluid uptake ability of hydrogel containing the drug with bare polymer. Zone of inhibition assay showed hydrogel containing 1% Ofloxacin to possess strong antimicrobial property Hemolysis assay demonstrated the hydrogel system to be non-hemolytic. Non-cytotoxic character of the hydrogel was confirmed using fibroblast cells. Cell adhesion studies showed non-attachment of fibroblasts to the polymer and improved cell proliferation simultaneously.
  • Item
    Photo polymerised PHEMA /PCL/PEG system as a potential wound dressing material
    (Journal of Bioactive and Compatible polymers, 2015-01) Rethikala, PK; Kalliyanakrishnan, V
  • Item
    Photopolymerized poly(2-hydroxyethyl methacrylate)/poly(epsilon-caprolactone)/poly(ethylene glycol) system as a potential wound dressing material
    (JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, 2015) Rethikala, PK; Kalliyana, KV
    Polymeric hydrogel systems based on poly(2-hydroxyethyl methacrylate), poly(epsilon-caprolactone), and poly(ethylene glycol) were prepared by photopolymerization using 2,4,6-trimethyl benzoyl diphenyl phosphine oxide as the photoinitiator. The structural details, morphology, and crystallinity were evaluated by Fourier transform infrared, scanning electron microscope, and X-ray diffraction analysis. The fluid uptake of the hydrogels was measured using swelling analysis. Based on a hemolysis assay, the prepared hydrogels were non-hemolytic. No attachment of fibroblasts to the hydrogel systems was observed. Stress-strain results indicated that the poly(2-hydroxyethyl methacrylate), poly(epsilon-caprolactone), and poly(ethylene glycol) hydrogel system (85:10:5) possessed better mechanical properties. Cytotoxic assessment by direct contact method of 85:10:5 systems found that the hydrogel was non-cytotoxic to L929 fibroblasts. This hydrophilic polymer system has a potential for wound dressing applications.