Browsing by Author "Rout, D"
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Item Central nervous system ganglioglioma. A clinicopathologic study.(Indian journal of cancer, 1996)Gangliogliomas are one of the uncommon tumours of central nervous system. Since these tumours have been associated with an indolent clinical course and benign biological behaviour, it is essential to make an accurate histopathological diagnosis of ganglioglioma. In this study the salient clinical and histopathological features in six patients with intracranial ganglioglioma are described.Item Craniospinal and spinal enterogenous cysts - Report of three cases(CLINICAL NEUROLOGY AND NEUROSURGERY, 1996)We report three cases of enterogenous cyst, one craniospinal and two spinal manifesting with features of spinal cord compression. In one the cyst was intramedullary in location and in the other two it was intradural, extramedullary. The unusual clinical presentation, location and magnetic resonance imaging (MRI) characteristics are discussed. None of the three patients had any vertebral anomaly or other congenital malformation. All patients had excellent outcome following surgery.Item Diagnostic utility of immunohistochemical techniques in intramedullary Schwann-cell tumours.(Indian journal of pathology & microbiology, 1993)Histopathologic features in two intramedullary schwann-cell tumours, closely resembled with those of fibrillary astrocytoma and could not be differentiated from each other by the conventional histochemical stains. However application of tumour markers-Glial fibrillary acidic protein (GFAP) and S-100 protein were found to be useful in differentiating these two tumours and thus helped in making an accurate histopathological diagnosis in these two patients.Item Diffuse form of primary leptomeningeal gliomatosis--a case report.(Indian journal of pathology & microbiology, 1994)Item Disseminated intra-cerebral microabscesses: a clinico-pathologic study.(Indian journal of pathology & microbiology, 1994)In this retrospective study, clinical and neuropathological features were analysed in eight patients with disseminated intracerebral microabscesses. All the patients presented with clinical features, suggestive of an encephalopathic process of an acute onset. Neuroradiological and laboratory investigations were not helpful in establishing the diagnosis in any patient during their hospital stay. All the eight patients died in the hospital and at autopsy disseminated intracerebral microabscesses were the most striking feature. In two patients hyphae of Candida albicans were demonstrated within the microabscesses. Gram negative bacilli in two patients and gram positive and gram positive cocci in one patient were demonstrated in the microabscesses. Disseminated intra-cerebral microabscesses are usually an unrecognised manifestation of central nervous system infections and should be considered in the differential diagnosis of patients with encephalopathy of unknown aetiology.Item Dysembryoplastic neuroepithelial tumour of the central nervous system--a case report.(Indian journal of pathology & microbiology, 1997)Dysembryoplastic neuroepithelial tumour (DNT) of the central nervous system is a recently recognized entity. We describe the clinical and characteristic histomorphological features in a patient with DNT. As this lesion carries a favourable prognosis, it becomes essential to make an accurate histopathological diagnosis.Item Dysplastic gangliocytoma of the cerebellum (Lhermitte-Duclos disease)--a case report with review of the literature.(Indian journal of cancer, 1992)Dysplastic gangliocytoma of the cerebellum is an uncommon malformative lesion and clinically manifest as a slow growing space occupying lesion. In this report, the characteristic clinical and histopathological features of a case of dysplastic gangliocytoma of the cerebellum are described.Item Effect of temporary vascular occulsion during surgery of cerebral aneursyms(NEUROLOGY INDIA, 1996) Rout, D; Nambiar, U; Misra, BK; Rout, ATemporary vascular occulsion during surgery fog cerebral aneursyms has been slow to gain acceptance as an elective procedure, This study presents the outcome in 115 cases in whom temporary vascular occulsion was needed during aneurysmal surgery, Elective temporary clipping was used in 55 cases and emergency temporary vascular occulsion was performed in 60 cases, Judicious use of temporary clips did not increase the overall morbidity or mortality, Rescue temporary clipping as an emergency measure in the face of intraoperative rupture has a deleterious effect as against elective use on the immediate as well as long term outcome of the patient, Use of elective temporary clipping in conjunction with adequate cerebral protective measures is advocated in difficult cases to facilitate definitive clipping of the aneursym in order to improve the overall outcome.Item Epidermoid cyst of the brain stem--a case report.(Indian journal of cancer, 1992)Epidermoid cysts occurring within the brain stem are extremely rare and only nine such cases are reported in the literature. In this report, we report a case of Intrapontine epidermoid cyst in a young female patient.Item Glial and cartilagenous differentiation in medulloblastoma--a case report.(Indian journal of pathology & microbiology, 1994)Item Gliomatosis cerebri--a case report.(Indian journal of cancer, 1996)Gliomatosis cerebri is a vary rare neoplastic lesion of the central nervous system. An intra-vitam diagnosis of gliomatosis cerebri can be suggested with a steleolactic biopsy of the lesion in conjunction with Magnetic Resonance Imaging (MRI) findings in the brain.Item Granular cell tumour (choristoma) of the neurohypophysis--a report of two cases.(Indian journal of pathology & microbiology, 1997)Granular cell tumours of the neurohypophysis are uncommon and only 30 cases are documented in the literature till 1994. In this communication, the salient clinical and histomorphological features in two patients with granular-cell tumour of the neurohypophysis are described.Item Immunohistochemical demonstration of mycobacterial antigens in intracranial tuberculoma.(Indian journal of experimental biology, 1991)Mycobacterial antigens have been demonstrated immunohistochemically in the paraffin sections of 10 intracranial tuberculous granulomas and the results were compared with the detection of acid fast bacilli by conventional Ziehl-Neelsen method. In none of the 10 specimens, acid fast bacilli were demonstrated while mycobacterial antigens were characterised as diffusely staining granular brownish-pink material within the cytoplasm of giant cells and macrophages. In 14 specimens of granulomatous lesions due to non-tuberculous aetiology, immunohistochemical stains were negative for mycobacterial antigen. Thus demonstration of mycobacterial antigen will be not only useful in establishing mycobacterial aetiology of a caseating intracranial granuloma but also can be used as an alternative method to the conventional Ziehl-Neelsen method.Item Intraventricular neurocytoma: a report of two cases.(Indian journal of cancer, 1994)Central neurocytomas are uncommon intracranial neoplasms. More than one hundred cases are documentated in the literature. In this report we describe the clinical and histopathological features in two patients with intraventricular neurocytoma. As the light microscopic features of neurocytoma resemble with that of an oligodendroglioma, it is essential to differentiate these two tumours, using either ultrastructural or immunohistochemical techniques.Item Lymphocytic hypophysitis--a report of a case.(Indian journal of pathology & microbiology, 1995)Item Medial trigonal arteriovenous malformations.(The Keio journal of medicine, 2000)A retrospective analysis of 48 patients of medial paratrigonal arteriovenous malformations (AVMs) which constituted 18% of the total 258. AVMs surgically managed in our institute for 16 years was carried out to study their clinical presentation, radiological features, operative approaches and functional outcome. While hemorrhage was the initial presenting symptom in 35, it was longstanding headache in 10, focal seizures in two and progressive weakness in one. However, 41 of these presented with bleed at the time of admission to our hospital and in 15 there was history of multiple bleeds. Twelve and eleven patients had field cut and hemiparesis respectively. Arterial supply to the malformation was quite uniform with posterior (43 patients) and anterior cerebral (25 patients) being the most frequent source. Venous drainage was predominantly into the galenic system (70%). Preoperative embolization was carried out in six patients. While the AVM was excised through a parasagittal interhemispheric approach in 34 patients, the nidus was approached through a direct transcortical (superior parietal lobule) approach in fourteen patients. There was only one operative mortality. Twelve patients whose preoperative fields were normal developed field cut postoperatively. An improvement of the preoperative field deficit was noted only in one patient. While eight of the ten patients with preoperative weakness improved and remained independent the remaining two were moderately disabled. Only two of the 10 patients who developed postoperative weakness remained severely disabled. Our operative results suggest that these AVMs which are prone to recurrent bleeds can be resected with acceptable morbidity. Hemianopia resulting from bleed or surgery is unlikely to improve.Item Nodular inflammatory mass of the dura mimicking a meningioma--a report of two cases.(Indian journal of pathology & microbiology, 1994)Histopathological examination of surgical specimens in two patients with an operative diagnosis of meningioma, revealed the presence of dense nodular aggregation of lymphocytes, plasma cells and conspicious absence of meningothelial components. Possibilities of lymphoreticular malignancy, myeloproliferative disorders and other causes for various inflammatory diseases were excluded by appropriate investigation in these two patients. Pathogenesis of this localised lymphocyte-plasma cell aggreation in the dura manifesting as a space-occupying lesion could not be defined in these two patients. It is emphasised that this benign lesion should be recognised as well as distinguished from secondary lymphomatous deposits and solitary plasmacytoma of the dura.Item Nucleolar organizer regions in pituitary adenomas.(Indian journal of pathology & microbiology, 1995)In this study, thirty-two non-functional and eighteen functional pituitary adenomas were analysed for the presence of argyrophilic nucleolar organizer regions (Ag-NORs) in paraffin sections, using an one-step silver-colloidal staining method. Differences in the mean Ag-NOR numbers of functional pituitary adenomas were statistically significant than those of non-functional pituitary adenomas. It is being emphasised that evaluation of Ag-NOR count is a more reliable index than the presence of mitotic figures in predicting the proliferative activity as well as possibility of recurrence in a patient with pituitary adenoma.Item Papillary meningioma--a clinicopathological study of six cases.(Indian journal of cancer, 1993)Papillary meningioma is a rare but a well recognised histological variant of meningioma. Only 52 cases are reported in literature till 1991. This report highlights the clinical and histopathological features of papillary meningioma in six patients. Significance of making an accurate histopathological diagnosis and its relevance in the management of patients with papillary meningioma is emphasised.Item Primary Ewing's sarcoma of the base of skull: a case report.(Indian journal of pathology & microbiology, 1993)Primary cranial Ewing's sarcoma is an exceptionally rare lesion and only eleven cases have so far been reported. In this report we describe a case of primary Ewing's sarcoma arising from the floor of middle cranial fossa. Salient clinical, neuroradiological and light microscopic features in this case are described. A brief review of earlier published cases of primary cranial Ewing's sarcoma are also presented.