Browsing by Author "SHIVAKUMAR, K"

Now showing 1 - 11 of 11
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    CELL-ADHESION AND GROWTH ON SYNTHETIC HYDROGEL BEADS
    (BULLETIN OF MATERIALS SCIENCE, 1989) SHIVAKUMAR, K; NAIR, RR; JAYAKRISHNAN, A; KARTHA, CC; VALIATHAN, MS
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    CERIUM DEPRESSES PROTEIN-SYNTHESIS IN CULTURED CARDIAC MYOCYTES AND LUNG FIBROBLASTS
    (MOLECULAR AND CELLULAR BIOCHEMISTRY, 1991)
    The present study examined the effect of Cerium on protein synthesis in cultured cardiac myocytes and lung fibroblasts exposed to normal and markedly subnormal levels of Mg2+. Cerium was found to have a general inhibitory effect on protein synthesis in these cell types, including the synthesis of myofibrillar proteins in the cardiac myocytes. Further, the effect of the metal ion was more pronounced in cells exposed to the Mg2+ -deficient medium. The possible implications of the observations are discussed.
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    ENDOTHELIN - A NOVEL REGULATORY PEPTIDE
    (CURRENT SCIENCE, 1992) SHIVAKUMAR, K; KARTHA, CC
    Endothelins are a family of structurally related vasoactive peptides synthesized by selected endothelial and epithelial cells. Endothelin is the most potent vasoactive biomolecule known to date. Recent evidences indicate that it is involved in several physiological and pathophysiological events. It will not be too long before the peptide stakes its claim to be the molecule of the decade.
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    GEOCHEMICAL BASIS OF TROPICAL ENDOMYOCARDIAL FIBROSIS
    (CURRENT SCIENCE, 1995) EAPEN, JT; SHIVAKUMAR, K; NAIR, RR; KARTHA, CC; VALIATHAN, MS
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    GEOCHEMICAL BASIS OF TROPICAL ENDOMYOCARDIAL FIBROSIS
    (CURRENT SCIENCE, 1994) VALIATHAN, MS; KARTHA, CC; NAIR, RR; SHIVAKUMAR, K; EAPEN, JT
    Endomyocardial fibrosis (EMF) has a marked preference for the tropics and the poor socio-economic class. Tropical soil is rich in minerals such as monazite and the endomyocardial samples of patients with EMF show higher levels of cerium - a major constituent of monazite - in combination with lower concentrations of magnesium. The geochemical hypothesis postulates that poor children are prose to develop magnesium deficiency because of insufficient intake and the higher growth needs for the element. The deficiency of magnesium promotes the absorption of cerium and enhances its toxicity which could form the basis for the initial injury in EMF.
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    INTERACTIONS OF THORIUM AND CERIUM WITH ADENINE-NUCLEOTIDES
    (BIOCHEMISTRY INTERNATIONAL, 1989) SHIVAKUMAR, K; APPUKUTTAN, PS; KARTHA, CC
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    MAGNESIUM-DEFICIENCY AND THE CARDIOVASCULAR-SYSTEM
    (CURRENT SCIENCE, 1995) SHIVAKUMAR, K
    Magnesium plays an important role in maintaining the structural and functional integrity of the cardiovascular system. Its influence on cardiac ion channels has immense clinical implications and is the subject of several incisive investigations. Magnesium deficiency may lead to a wide spectrum of vascular and cardiac complications. This article reviews evidence that magnesium deficiency promotes hypercoagulability of blood, atherogenesis, vasoconstriction, cardiac arrhythmias and cardiac muscle damage. Mechanisms underlying these effects are briefly discussed. Further, it is proposed that the myocardial lesions of chronic magnesium deficiency may result from recurrent episodes of mild ischaemia and reperfusion and consequent free-radical generation.
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    PARADOXICAL EFFECT OF CERIUM ON COLLAGEN-SYNTHESIS IN CARDIAC FIBROBLASTS
    (JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 1992)
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    PROBING THE HEART OF CARDIOMYOPATHIES
    (CURRENT SCIENCE, 1993) KARTHA, CC; SHIVAKUMAR, K
    Current knowledge of aetiopathogenesis of various forms of human cardiomyopathy is reviewed in this article. There are overwhelming evidences to suggest a pathogenetic link between persistent viral infection, induction of autoimmunity (influenced by immune response determinants in the HLA region) and alteration in the differentiated functions of the myocardium in dilated cardiomyopathy. Genetic studies have identified specific defects in patients with hypertrophic cardiomyopathy but the cellular basis of the disease remains unresolved. Endomyocardial diseases associated with hypereosinophilic syndrome and endomyocardial fibrosis of the tropics appear to be two separate entities. A unifying link among endomyocardial fibrosis of diverse causes could be the uniform response of the 'cardiac tissue to injuries of heterogenous nature. Application of microtechniques to endomyocardial biopsy promises definitive information on aetiopathogenesis of cardiomyopathies.
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    SYNTHETIC HYDROGEL MICROSPHERES AS SUBSTRATA FOR CELL-ADHESION AND GROWTH
    (IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY, 1989) SHIVAKUMAR, K; NAIR, RR; JAYAKRISHNAN, A; THANOO, BC; KARTHA, CC