Browsing by Author "Sankar, V"

Now showing 1 - 4 of 4
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    Growth and survival of cells in biosynthetic poly vinyl alcohol-alginate IPN hydrogels for cardiac applications
    (COLLOIDS AND SURFACES B-BIOINTERFACES, 2013) Thankam, FG; Muthu, J; Sankar, V; Gopal, RK
    Biosynthetic hydrogels of poly vinyl alcohol-calcium alginate were prepared as semi (semi-IPN hydrogel, PAH) and full interpenetrating polymeric network (IPN hydrogel, PAHG) for tissue engineering of cardiac tissue. The biological response of these hydrogels was studied. The IPN hydrogel exhibits amphiphilic nature and moderate equilibrium water content. The IPN hydrogel inherits the water as structured one along with more free water. The IPN hydrogel has adequate mechanical strength and fatigue life and stability in physiological media over the semi-IPN hydrogel. The structured water along with more free water in IPN hydrogel promotes blood compatibility, cell adhesion and proliferation and maintains three dimensional growths of L929 fibroblast and H9C2 cardiomyoblasts. IPN hydrogel maintain long term cell viability and infiltration with exchange of nutrients in the interstices of the hydrogel. The IPN hydrogel, PAHG is a promising material for engineering cardiac tissue. (C) 2013 Elsevier B.V. All rights reserved.
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    Studies on chemically crosslinkable carboxy terminated-poly(propylene fumarate-co-ethylene glycol)-acrylamide hydrogel as an injectable biomaterial
    (BIOMEDICAL MATERIALS, 2009) Kallukalam, BC; Jayabalan, M; Sankar, V
    Carboxy terminated-poly(propylene fumarate)-co-ethylene glycol) (CT-PPF-co-PEG) was prepared and set into crosslinked hydrogel material with acrylamide. The setting studies reveal that this copolymer system can be used as an injectable material. The hydrogel material exhibits a higher degree of swelling, good mechanical strength and flexibility. The hydrogel favours adhesion of L929 fibroblast cells without proliferation on the surface. However, cardiac fibroblast cells (isolated from new born rat (Wistar) hearts) adhere and proliferate on the hydrogel due to the formation of synergistic hydrophilic-hydrophobic surface-by-surface reorganization.
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    Studies on chemically crosslinkable carboxy terminated-poly(propylene fumarate-co-ethylene glycol)-acrylamide hydrogel as an injectable biomaterial.
    (Biomedical materials (Bristol, England), 2009)
    Carboxy terminated-poly(propylene fumarate)-co-ethylene glycol) (CT-PPF-co-PEG) was prepared and set into crosslinked hydrogel material with acrylamide. The setting studies reveal that this copolymer system can be used as an injectable material. The hydrogel material exhibits a higher degree of swelling, good mechanical strength and flexibility. The hydrogel favours adhesion of L929 fibroblast cells without proliferation on the surface. However, cardiac fibroblast cells (isolated from new born rat (Wistar) hearts) adhere and proliferate on the hydrogel due to the formation of synergistic hydrophilic-hydrophobic surface-by-surface reorganization.