Browsing by Author "Shanthikrishna"

Now showing 1 - 2 of 2
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    Fluorimetric detection of hypochlorite using albumin stabilized gold nanoclusters
    (Sensors and Actuators B., 2015-01) Gopu, CL; Shanthikrishna; Sreenivasan, K
    Development of simple and effective techniques for hypochlorite (HOCl) detection at trace levels are of great importance due to its wide spread use as disinfectant especially for water treatments including drinking water. A fluorescence ‘turn-off’ detection technique for HOCl based on bovine serum albumin (BSA) stabilized gold nanoclusters was developed. The fluorescence quenching of gold nanoclusters by HOCl is due to selective oxidation of amino acid residues in BSA that could be seen visually under UV lamp as color change within 2 min. The current method is rapid, simple and enables sensitive determination of HOCl with a detection limit of 0.1 × 10−6 M. The method showed high selectivity over other common ions present in the environment and was applied to detect HOCl in real water samples.
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    Functionalized carbon dots enable simultaneous bone crack detection and drug deposition
    (J. Mater. Chem B., 2015-01) Shanthikrishna; Radhakumary, C; Antony, M; Sreenivasan, K
    Recently, carbon dots (CDs) have become one of the most sought nanomaterials for biological applications owing to their excellent fluorescence, chemical inertness and biocompatibility. This article depicts the generation of a fluorescent nano probe using CDs for viewing bone cracks and simultaneous drug delivery to the cracked or infected sites. Water soluble polyethylene glycol diamine capped CDs were conjugated with glutamic acid (GA), a calcium targeting ligand, and ciprofloxacin as an antibacterial model drug. Physicochemical characterizations, cytotoxicity evaluation, haemolysis and antibacterial activity studies of the synthesized probe and its ability to target onto bone are demonstrated. Our results indicate that there is significant scope in developing functionalized CDs as theranostic agents.