Browsing by Author "Sudheesh, KV"

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    Cyclometalated Ir(III) complex as lysosome targeted photodynamic therapeutic agent for integrated imaging and therapy in cancer cells.
    (Chemistry - A European Journal, 2018-06) Sudheesh, KV; Jayaram, PS; Samanta, A; Kochan, S; Bejoymohandas, KS; Jayasree, RS; Ajayaghosh, A
    Organelle targeted photosensitizers (PSs) having luminescence properties are potential theranostic agents for simultaneous luminescence imaging and photodynamic therapy. Herein, we report a water soluble luminescent cyclometalated Ir(III) complex, Ir-Bp-Ly as lysosome targeted theranostic probe. Ir-Bp-Ly exhibits exceptional photophysical properties of good triplet state quantum yield (0.90), singlet oxygen generation quantum yield (0.71 at pH 4) and long lifetime (1.47 µs). Interestingly, Ir-Bp-Ly localized mostly in the lysosome because of the presence of morpholine units, suggesting its potential as a lyso-tracker. Ir-Bp-Ly displayed notable PDT effect in C6 glioma cells, as these PS efficiently generated ROS owing to the close proximity energy levels between triplet energy states of Ir-Bp-Ly and molecular oxygen (3O2). The mechanism of cell death was studied through caspase-3/7 and flow cytometry analysis that clearly established the apoptotic pathway.