Browsing by Author "Thomas, S"

Now showing 1 - 13 of 13
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    CURRENT STATE OF INTERNATIONAL EPILEPSY GUIDELINES
    (EPILEPSIA, 2015) Sauro, K; Wiebe, S; Pedley, T; Dunkley, C; Kumlien, E; Moshe, S; Nakasato, N; Perucca, E; Senties, H; Thomas, S; Wang, Y; Wilmshurst, J; Jette, N
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    Effect of dehydrochlorination of PVC on miscibility and phase separation of binary and ternary blends of poly(vinyl chloride), poly(ethylene-co-vinyl acetate) and poly(styrene-co-acrylonitrile)
    (POLYMER INTERNATIONAL, 1997) Lizymol, PP; Thomas, S; Jayabalan, M
    The enhancement of miscibility at the lower critical solution temperature (LOST) of the blends poly(vinyl chloride)/poly(ethylene-co-vinyl acetate) (PVC/EVA), poly(vinyl chloride)/poly(styrene-co-acrylonitrile) (PVC/SAN) and poly(vinyl chloride)/poly(ethylene-co-vinyl acetate)/poly(styrene-co-acrylonitrile) (PVC/EVA/SAN) was observed at the micron level. Such miscibility is attributed to the dehydrochlorination and formation of hydrogen bonds between blend components. However, macrolevel immiscibility of these blends heated to the LCST was observed. Such microdomain compatibility of these blends gives a synergistic character. Brittle-type failure observed for LCST samples testifies to the synergism in treated blends.
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    ELECTROCLINICAL PREDICTORS OF OUTCOME IN WEST SYNDROME & ITS RELATIONSHIP TO TRACTOGRAPHIC ABNORMALITIES
    (EPILEPSIA, 2015) Menon, R; Sundar, A; Nair, JS; Radhakrishnan, A; Thomas, B; Thomas, S
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    Evaluation of in-vitro cytotoxicity and cellular uptake efficiency of zidovudine-loaded solid lipid nanoparticles modified with Aloe Vera in glioma cells
    (MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2016) Joshy, KS; Sharma, CP; Kalarikkal, N; Sandeep, K; Thomas, S; Pothen, LA
    Zidovudine loaded solid lipid nanoparticles of stearic acid modified with Aloe Vera (AV) have been prepared via simple emulsion solvent evaporation method which showed excellent stability at room temperature and refrigerated condition. The nanoparticles were examined by Fourier transform infrared spectroscopy (FT-IR), which revealed the overlap of the AV absorption peak with the absorption peak of modified stearic acid nanopartides. The inclusion of AV to stearic acid decreased the crystallinity and improved the hydrophilidty of lipid nano particles and thereby improved the drug loading efficacy of lipid nanopartides. Dynamic light scattering (DLS) and transmission electron microscopy (TEM) imaging revealed that, the average particle size of unmodified (bare) nanoparticles was 45.66 +/- 12.22 nm and modified solid lipid nanoparticles showed an average size of 265.61 +/- 80.44 nm. Solid lipid nanoparticles with well-defined morphology were tested in vitro for their possible application in drug delivery. Cell culture studies using C6 glioma cells on the nanoparticles showed enhanced growth and proliferation of cells without exhibiting any toxicity. In addition, normal cell morphology and improved uptake were observed by fluorescence microscopy images of rhodamine labeled modified solid lipid nanoparticles compared with unmodified nanoparticles. The cellular uptake study suggested that these nanopartides could be a promising drug delivery system to enhance the uptake of antiviral drug by brain cells and it could be a suitable drug carrier system for the treatment of HIV. (C) 2016 Elsevier B.V. All rights reserved.
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    IMPACT OF GENDER ON OUTCOME OF EPILEPSY
    (EPILEPSIA, 2009) Gopinath, M; Sarma, S; Thomas, S
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    Lower Incidence of Neurocysticercosis among Persons with Active Epilepsy in Kerala, South India - A Case-Control Study
    (NEUROLOGY, 2013) Syam, UK; Cherian, A; Thomas, S; Radhakrishnan, K; Rajashekhar, V; Oommen, A
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    RARE COPY NUMBER VARIATION IS COMMON IN ROLANDIC EPILEPSY AND DISRUPTS KNOWN EPILEPSY GENES
    (EPILEPSIA, 2014) Addis, L; Newhouse, S; Topp, SD; Carabello, R; Pruna, D; Thomas, S; Pal, DK
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    Rheological behaviour of binary and ternary blends of poly(vinyl chloride) (PVC), poly(ethylene-co-vinyl acetate) (EVA) and poly(styrene-co-acrylonitrile) (SAN)
    (EUROPEAN POLYMER JOURNAL, 1997)
    The solution rheology of blends of poly(vinyl chloride), poly(ethylene-co-vinyl acetate) (PVC/EVA), poly(vinyl chloride)/poly(styrene-co-acrylonitrile) (PVC/SAN), poly(ethylene-co-vinyl acetate)/poly(styrene-co-acrylonitrile) (EVA/SAN) and PVC/EVA/SAN have been studied in cyclohexanone as a function of shear rate and composition. These investigations indicate the compatibility of PVC/EVA, partial miscibility of PVC/SAN and the complete immiscible nature of EVA/SAN blends in solution. In the PVC/EVA/SAN ternary blend, both miscible and immiscible compositions exist. The compatible blend exhibits viscosity equal to the additive value under shear and incompatible blend exhibits viscosity lower than the additive value under shear. (C) 1997 Elsevier Science Ltd.
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    Significance of facial dysmorphism in children of mothers with epilepsy
    (EPILEPSIA, 2007) John, J; Haroon, N; K, EE; Thomas, S
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    Simultaneous synthesis of carbon quantum dots, fluorescent probes, biofilms and hydrochar from sustainable vermicompost for versatile applications
    (Chemical Papers, 2023-03) Rekha, RK; Arunima, R; Siji, KM; Jijo, TK; Hema, S; Jayasree, RS; Pothen, LA; Thomas, S
    Sustainable and renewable sources of nanomaterial synthesis are a demanding approach. This work provides new insight into the versatile applications of materials derived from vermicompost. The report explains the simultaneous conversion of vermicompost to hydrophilic and stable carbon quantum dots (CDs) and hydrochar. The as-prepared CDs exhibit broad range emission spectrum from blue (400) to red (600 nm) with excitation dependent emission phenomenon. The films prepared using the CDs showed higher cellular uptake and intracellular localization. The FTIR results supported the existence of hydroxyl, amine, carboxylate and carbonyl groups on the surfaces of the CD. The zeta potential value of CDs was − 38.5. The ion absorption was tested for different cations and was maximum for Fe3+ ions, even for micromolar solutions. The hydrochar produced was used for adsorption of methylene blue dye from water and it was found that 80% of dye was removed after 12 h. of treatment. Thus, we suggest vermicompost as a promising alternative for nanomaterial synthesis.
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    Success factors of public funded R&D projects
    (CURRENT SCIENCE, 2015) Nagesh, DS; Thomas, S
    Research and development (R&D) projects which are classified into basic research, applied research and product development are being carried out by industries, academia and R&D institutes. Such projects funded by government agencies are common among nations all around the globe. They are basically aimed at developing national science and technological competence than direct market orientation or commercialization and are in many respects different from industrial R&D projects. Most of them are handled by the academic/R&D institutions. Their target is long term, need high intellectual input, benefits may not be tangible and risk is high. The outcome of such R&D projects is not always successful and the underlying reasons may vary widely. Various factors have been identified and projected: out of which many are common, some are contextual and the rest are even contradicting. Not many attempts were carried out to identify the factors which contribute to the success of projects carried out by academic/R&D institutions, which is of high relevance to the Indian context. Hence in this article, we attempt to review various factors contributing to the success of projects which are funded by the government and grouped them into common eight categories such as type of the project, leader's competence, team, environment, funding and other resources, management support, collaboration and degree of difficulty.
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    The dilemma of arranged marriages in people with epilepsy. An expert group appraisal
    (EPILEPSY & BEHAVIOR, 2016) Singh, G; Pauranik, A; Menon, B; Paul, BS; Selai, C; Chowdhury, D; Goel, D; Srinivas, HV; Vohra, H; Duncan, J; Khona, K; Modi, M; Mehndiratta, MM; Kharbanda, P; Goel, P; Shah, P; Bansal, R; Addlakha, R; Thomas, S; Jain, S; Shah, U; Saxena, VS; Sharma, V; Nadkarni, VV; Wakankar, Y
    Introduction: Matrimony remains a challenging psychosocial problem confronting people with epilepsy (PWE). People with epilepsy are less likely to marry; however, their marital prospects are most seriously compromised in arranged marriages. Aims: The aim of this study was to document marital prospects and outcomes in PWE going through arranged marriage and to propose optimal practices for counseling PWE contemplating arranged marriage. Methods: A MEDLINE search and literature review were conducted, followed by a cross-disciplinary meeting of experts to generate consensus. Results: People with epilepsy experience high levels of felt and enacted stigma in arranged marriages, but the repercussions are heavily biased against women. Hiding epilepsy is common during marital negotiations but may be associated with poor medication adherence, reduced physician visits, and poor marital outcome. Although divorce rates are generally insubstantial in PWE, divorce rates appear to be higher in PWE undergoing arranged marriages. In these marriages, hiding epilepsy during marital negotiations is a risk factor for divorce. Conclusions: In communities in which arranged marriages are common, physicians caring for PWE are best equipped to counsel them about their marital prospects. Marital plans and aspirations should be discussed with the family of the person with epilepsy in a timely and proactive manner. The benefits of disclosing epilepsy during marital negotiations should be underscored. (C) 2016 Elsevier Inc. All rights reserved.