Fluorescent and superparamagnetic hybrid quantum clusters for magnetic separation and imaging of cancer cells from blood

dc.contributor	Durgadas, C. V.
dc.contributor	Sharma, Chandra P.
dc.contributor	Sreenivasan, K.
dc.date.accessioned	2012-12-04T11:44:08Z
dc.date.available	2012-12-04T11:44:08Z
dc.date.issued	2011
dc.description.abstract	We demonstrate here the generation of fluorescent superparamagnetic quantum clusters through a greener aqueous route by fusing highly fluorescent gold clusters with superparamagnetic nanoparticles. We conjugated transferrin onto the hybrid clusters to get cell accessibility and assessed their hemocompatibility and cytotoxicity. The ability of the clusters to selectively remove cancer cell lines (C6 glioma cells) from fluids including blood and the fluorescent imaging of the separated cells is demonstrated. The pattering of the clusters in response to an external magnetic field is also shown. Efficient cancer cell separation, imaging and magnetic pattering can be realized by the highly hemocompatible and noncytotoxic hybrid clusters reported here. It seems the probe has potential for further exploration in multimodal imaging of circulating cancer cells.
dc.identifier.citation	NANOSCALE. 3; 11; 4780-4787	en_US
dc.identifier.uri	http://dx.doi.org/10.1039/c1nr10900f
dc.identifier.uri	https://dspace.sctimst.ac.in/handle/123456789/513
dc.publisher	NANOSCALE
dc.subject	Biomaterials
dc.title	Fluorescent and superparamagnetic hybrid quantum clusters for magnetic separation and imaging of cancer cells from blood