Cell-mimetic coatings for immune spheres

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dc.contributor.authorKaladhar, K
dc.contributor.authorRenz, H
dc.contributor.authorSharma, CP
dc.date.accessioned2017-03-10T03:25:51Z
dc.date.available2017-03-10T03:25:51Z
dc.date.issued2014
dc.description.abstractExtrinsically induced or engineered cells are providing new therapeutic means in emerging fields such as cell therapeutics, immunomodulation and regenerative medicine. We are demonstrating a spatial induction method using lipid coatings, which can change signal presentation strength from material surface to adherent macrophage cells, that induce early cell-cell interaction leading to organotypic morphology. For that, we have developed a cell mimetic lipid coating with a rafts size to the order of transmembrane proteins (<10 nm) with enhanced lateral elastic properties. Such surface coatings are capable of reducing adherent macrophage spreading, while enabling early induction of cell-cell interaction to form organotypic macrophage colonies or "spheres" (M-spheres). (C) 2014 Elsevier B.V. All rights reserved.
dc.identifier.citation123 ,;845-851en_US
dc.identifier.uri10.1016/j.colsurfb.2014.10.029
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/9424
dc.publisherCOLLOIDS AND SURFACES B-BIOINTERFACES
dc.subjectBiophysics; Chemistry; Materials Science
dc.titleCell-mimetic coatings for immune spheres
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