Polyhedral Oligomeric Silsesquioxane-F68 Hybrid Vesicles for Folate Receptor Targeted Anti-Cancer Drug Delivery

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dc.contributor.authorNair, BP
dc.contributor.authorVaikkath, D
dc.contributor.authorNair, PD
dc.date.accessioned2017-03-10T03:28:08Z
dc.date.available2017-03-10T03:28:08Z
dc.date.issued2014
dc.description.abstractPolyhedral Oligomeric Silsesquioxane (POSS)-F68 hybrid vesicles with an average diameter of 700 nm are produced using a stable solution of heterofunctional POSS having 3-aminopropyl and vinyl groups and pluronic F68 in ethanol-water mixture. Thermogram and zeta potential values evidence the spontaneous self-assembly of POSS into bilayers through H-bonding interaction between the aminopropyl groups, and the effective stabilization of the POSS-bilayers by amphiphilic F68 during solvent-evaporation to form the vesicles. The vesicles are noncytotoxic and dispersible in aqueous solvents through steric stabilization provided by the hydrophilic F68. A highly facile coinclusion method has been used for making doxorubicin and folic acid loaded vesicles. Doxorubicin loaded in the vesicles exhibits a controlled release profile in phosphate buffered saline. Confocal microscopic and flow cytometric studies on the endocytosis of the vesicles by HeLa and HOS cells prove that a noncovalent entrapment of excess folic acid in the vesicles through H-bonding is sufficient to enhance the uptake significantly. POSS-F68 vesicles in combination with folic acid and a chemotherapeutic can have potential for targeted intracellular anti-cancer drug delivery.
dc.identifier.citation30 ,1;340-347en_US
dc.identifier.uri10.1021/la4036997
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/10255
dc.publisherLANGMUIR
dc.subjectChemistry; Materials Science
dc.titlePolyhedral Oligomeric Silsesquioxane-F68 Hybrid Vesicles for Folate Receptor Targeted Anti-Cancer Drug Delivery
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