L-type calcium channel blockers and EGTA enhance superoxide production in cardiac fibroblasts

Simple item page
dc.contributorShivakumar, K
dc.contributorKumaran, C
dc.date.accessioned2012-12-04T11:44:33Z
dc.date.available2012-12-04T11:44:33Z
dc.date.issued2001
dc.description.abstractSince the recognition of the importance of calcium ions to cardiac contractility, the effects of alterations in calcium homeostasis on cardiac myocyte function have attracted immense attention. However, the possibility that changes in extracellular calcium concentration or the administration of calcium channel blockers may exert significant effects on cardiac fibroblasts has not hitherto been explored. This communication presents evidence, for the first time, that EGTA, calcium-free incubation and L-type calcium channel blockers increase endogenous superoxide production in adult rat cardiac fibroblasts. A combination of ryanodine and EGTA was found to have an even greater effect. The observations indicate that extracellular calcium levels influence endogenous superoxide production in cardiac fibroblasts and support the postulation that myocardial fibroblasts may contribute to the cardiac effects of calcium channel blockers and alterations in extracellular calcium concentration. (C) 2001 Academic Press.
dc.identifier.citationJOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 33; 2; 373-377en_US
dc.identifier.urihttp://dx.doi.org/10.1006/jmcc.2000.1309
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/pubmed/11162140
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/713
dc.publisherJOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
dc.subjectCardiology
dc.titleL-type calcium channel blockers and EGTA enhance superoxide production in cardiac fibroblasts
Files
Collections
Journal Articles