The influence of photodynamic therapy on the wound healing process in rats

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dc.contributorJayasree, RS
dc.contributorGupta, AK
dc.contributorRathinam, K
dc.contributorMohanan, PV
dc.contributorMohanty, M
dc.date.accessioned2012-12-04T11:45:32Z
dc.date.available2012-12-04T11:45:32Z
dc.date.issued2001
dc.description.abstractIn photodynamic therapy (PDT), photosensitisers (PS) are used along with lasers for the treatment of tumors. The combined effect of photosensitisers and lasers on the wound healing process is studied using delta -aminolevulinic acid (ALA) (5 mg/kg) and hematoporphyrin derivative (HPD) (5 mg/kg) as photosensitisers in the open excision wounds of rats. The lasers used were He-Ne laser (3 J/cm(2)) and Nd: YAG laser (30 J/cm(2)). This study is important for understanding the healing process involved after PDT. Open excision wounds treated with He-Ne lasers in animals that received ALA as photosensitiser showed complete wound closure at the earliest by 13 +/- 1 days, and with results obtained for HPD and the combination of lasers with complete closing by 14 +/- 1 days. However, the control group of animals that received ALS or HPD with no laser treatment showed wound healing on the twentieth and eighteenth days with a deviation of one day and two days, respectively. ALA with the combination of Nd: YAG and He-Ne lasers and HPD with He-Ne laser alone does not show quicker wound healing effects. Histopathological results also gave similar results. Tensile strength measurements do not vary significantly from control group to the test group.ALA along with He-Ne laser of HPD along with the combination of He-Ne and low power Nd-YAG lasers are found to be ideal methods for quickening the wound healing process in rat.
dc.identifier.citationJOURNAL OF BIOMATERIALS APPLICATIONS. 15; 3; 176-186en_US
dc.identifier.urihttp://dx.doi.org/10.1106/9335-Q0NC-5XCQ-KBYK
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/pubmed/11261599
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/1198
dc.publisherJOURNAL OF BIOMATERIALS APPLICATIONS
dc.subjectExperimental Medicine
dc.titleThe influence of photodynamic therapy on the wound healing process in rats
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