Failure to find association between febrile seizures and SCN1A rs3812718 polymorphism in south Indian patients with mesial temporal lobe epilepsy and hippocampal sclerosis

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dc.contributor.authorBalan, S
dc.contributor.authorVellichirammal, NN
dc.contributor.authorBanerjee, M
dc.contributor.authorRadhakrishnan, K
dc.date.accessioned2017-03-10T03:26:41Z
dc.date.available2017-03-10T03:26:41Z
dc.date.issued2012
dc.description.abstractWe compared the allele and genotype frequencies of SCN1A SNP rs3812718 between patients with MTLE-HS of south Indian ancestry with and without febrile seizures (FS) and with ethnically matched controls. While we observed no significant difference in allele and genotype frequencies of rs3812718 between MTLE-HS patients with and without FS, A allele and AA genotype were overrepresented in MTLE-HS patients when compared to controls. We conclude that in the population studied, although rs3812718 polymorphism increases the susceptibility to MTLE-HS, this is not by increasing the susceptibility to FS. (C) 2012 Elsevier B.V. All rights reserved.
dc.identifier.citation101 ,3;288-292en_US
dc.identifier.uri10.1016/j.eplepsyres.2012.04.009
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/9749
dc.publisherEPILEPSY RESEARCH
dc.subjectNeurosciences & Neurology
dc.titleFailure to find association between febrile seizures and SCN1A rs3812718 polymorphism in south Indian patients with mesial temporal lobe epilepsy and hippocampal sclerosis
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