Hybrid alginate-polyester bimodal network hydrogel for tissue engineering - Influence of structured water on long-term cellular growth

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dc.contributor.authorFinosh, GT
dc.contributor.authorJayabalan, M
dc.contributor.authorVandana, S
dc.contributor.authorRaghu, KG
dc.date.accessioned2017-03-10T03:27:03Z
dc.date.available2017-03-10T03:27:03Z
dc.date.issued2015
dc.description.abstractThe development of biodegradable scaffolds (which promote cell-binding, proliferation, long-term cell viability and required biomechanical stability) for cardiac tissue engineering is a challenge. In this study, biosynthetic amphiphilic hybrid hydrogels were prepared using a graft comacromer of natural polysaccharide alginate and synthetic polyester polypropylene fumarate (PPF). Monomodal network hydrogel (HPAS-NO) and bimodal network hydrogel (HPAS-AA) were prepared. Between the two hydrogels, HPAS-AA hydrogel excels over the HPAS-NO hydrogel. HPAS-AA hydrogel is mechanically more stable in the culture medium and undergoes gradual degradation in vitro in PBS (phosphate buffered saline). HPAS-AA contains nano-porous structure and acquires structured water (non-freezing-bound water) (53.457%) along with free water (11.773%). It absorbs more plasma proteins and prevents platelet adsorption and hemolysis when contacted with blood. HPAS-AA hydrogel is cytocompatible and promote 3D cell growth (approximate to 170%) of L929 fibroblast even after 18 days and H9C2 cardiomyoblasts. The enhanced and long-term cellular growth of HPAS-AA hydrogel is attributed to the cell responsive features of structured water. HPAS-AA hydrogel can be a better candidate for cardiac tissue engineering applications. (c) 2015 Elsevier B.V. All rights reserved.
dc.identifier.citation135 ,;855-864en_US
dc.identifier.uri10.1016/j.colsurfb.2015.03.020
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/9862
dc.publisherCOLLOIDS AND SURFACES B-BIOINTERFACES
dc.subjectBiophysics; Chemistry; Materials Science
dc.titleHybrid alginate-polyester bimodal network hydrogel for tissue engineering - Influence of structured water on long-term cellular growth
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