In vitro release study and antimicorbial property evaluation of ofloxacin loaded poly (2-hydroxyethyl methacrylate)/poly (caprolactone)/poly (ethylene glycol) hydrogel system for burn wound management
| dc.contributor.author | Rethikala, PK | |
| dc.contributor.author | Nair, RP | |
| dc.contributor.author | Krishnan, LK | |
| dc.contributor.author | Krishnan, VK | |
| dc.date.accessioned | 2017-02-08T07:05:59Z | |
| dc.date.available | 2017-02-08T07:05:59Z | |
| dc.date.issued | 2017-01 | |
| dc.description.abstract | Monomer 2-hydroxy ethyl methacrylate containing small amounts of poly(caprolactone) and poly(ethylene glycol) incorporated with an antibiotic ofloxacin was polymerized by photo-polymerization technique using 2,4,6 trimethyl benzoyl diphenyl phosphine oxide (TPO) as photo-initiator. Encapsulation efficiency and in vitro drug release was studied using UV-visible spectroscopy. Swelling analysis was resorted to compare fluid uptake ability of hydrogel containing the drug with bare polymer. Zone of inhibition assay showed hydrogel containing 1% Ofloxacin to possess strong antimicrobial property Hemolysis assay demonstrated the hydrogel system to be non-hemolytic. Non-cytotoxic character of the hydrogel was confirmed using fibroblast cells. Cell adhesion studies showed non-attachment of fibroblasts to the polymer and improved cell proliferation simultaneously. | en_US |
| dc.identifier.citation | Rethikala PK, Nair RP, Krishnan LK, Krishnan VK. In vitro release study and antimicorbial property evaluation of ofloxacin loaded poly (2-hydroxyethyl methacrylate)/poly (caprolactone)/poly (ethylene glycol) hydrogel system for burn wound management. Journal of Drug Delivery and therapeutics. 2017;7(1):13-20 | en_US |
| dc.identifier.uri | http://dx.doi.org/10.22270/jddt.v6i6.1351 | |
| dc.identifier.uri | https://dspace.sctimst.ac.in/handle/123456789/2917 | |
| dc.publisher | Journal of Drug Delivery and therapeutics | en_US |
| dc.subject | Ofloxacin, Encapsulation efficiency, Hydrogel, Antimicrobial | en_US |
| dc.title | In vitro release study and antimicorbial property evaluation of ofloxacin loaded poly (2-hydroxyethyl methacrylate)/poly (caprolactone)/poly (ethylene glycol) hydrogel system for burn wound management | en_US |
| dc.type | Article | en_US |