DIAGNOSTIC-SIGNIFICANCE OF CIRCULATING IMMUNE-COMPLEXES IN PATIENTS WITH PULMONARY TUBERCULOSIS

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dc.contributorRADHAKRISHNAN, VV
dc.contributorMATHAI, A
dc.contributorSUNDARAM, P
dc.date.accessioned2012-12-04T11:43:51Z
dc.date.available2012-12-04T11:43:51Z
dc.date.issued1992
dc.description.abstractA polyethylene glycol (PEG) precipitation method was used to examine sera of patients with active pulmonary tuberculosis (PT), leprosy and non-tuberculous pulmonary diseases and of healthy control subjects for immune complexes (ICs). Mycobacterium tuberculosis antigen 5 was detected in the ICs in 80% of patients with PT by the indirect (sandwich) enzyme-linked immunosorbent assay (ELISA). Detection of mycobacterial antigen in ICs has diagnostic potential as an adjunct in the laboratory diagnosis of PT, particularly when repeated bacteriological investigations for M. tuberculosis in clinical specimens are negative. Levels of ICs tend to decrease with the duration of anti-tuberculosis chemotherapy and their detection can also be used to assess the clinical response to therapy in patients with PT.
dc.identifier.citationJOURNAL OF MEDICAL MICROBIOLOGY. 36; 2; 128-131en_US
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/363
dc.publisherJOURNAL OF MEDICAL MICROBIOLOGY
dc.subjectImmunology
dc.titleDIAGNOSTIC-SIGNIFICANCE OF CIRCULATING IMMUNE-COMPLEXES IN PATIENTS WITH PULMONARY TUBERCULOSIS
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