Synthesis and characterization of a noncytotoxic, X-ray opaque polyurethane containing iodinated hydroquinone bis(2-hydroxyethyl) ether as chain extender for biomedical applications

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dc.contributor.authorKiran, S
dc.contributor.authorJoseph, R
dc.date.accessioned2017-03-10T03:28:51Z
dc.date.available2017-03-10T03:28:51Z
dc.date.issued2014
dc.description.abstractAn iodinated urethane polymer that does not require addition of X-ray attenuating additives to impart Xray opacity was synthesized and characterized for biomedical applications. A new X-ray opaque diiodo compound, namely, 2,2'-(2,5-diiodobenzene-1,4-diyl)bis(oxy)diethanol (DBD), was synthesized by iodinating hydroquinone bis(2-hydroxyethyl) ether and this compound was used as chain extender during polyurethane synthesis so that X-ray opacity could be imparted to the polymer formed. X-ray opaque polyurethane (XPU) was synthesized by reacting 1,6-diisocyanatohexane with poly(hexamethylene carbonate) diol and DBD. X-ray opacity of XPU was measured with a fluoroscopy machine using BaSO4-filled polyurethane as controls. Radiographic images showed that XPU sample had X-ray opacity equivalent to 15 wt % BaSO4-filled polymer. In vivo imaging in a rabbit model showed that the material could be readily distinguishable from bones. XPU was found to be hemocompatible and noncytotoxic to L929 fibroblast cell lines. Optical transparency measurements using ultraviolet-visible spectrophotometer showed that XPU transmitted 85% of visible light. (C) 2013 Wiley Periodicals, Inc.
dc.identifier.citation102 ,9;3207-3215en_US
dc.identifier.uri10.1002/jbm.a.34997
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/10530
dc.publisherJOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
dc.subjectEngineering; Materials Science
dc.titleSynthesis and characterization of a noncytotoxic, X-ray opaque polyurethane containing iodinated hydroquinone bis(2-hydroxyethyl) ether as chain extender for biomedical applications
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