Toxicity evaluation of dextran coated ferrite nanomaterials after acute oral exposure to Wistar rats.

Simple item page
dc.contributor.authorSyama, S
dc.contributor.authorReshma, SC
dc.contributor.authorLeji, B
dc.contributor.authorAnju, M
dc.contributor.authorSreekanth, PJ
dc.contributor.authorVarma, HK
dc.contributor.authorMohanan, PV
dc.date.accessioned2015-01-09T09:18:26Z
dc.date.available2015-01-09T09:18:26Z
dc.date.issued2014
dc.description.abstractDextran Coated Ferrite Nanomaterials (DFNM) of size <25 nm was synthesized, characterized and the acute oral toxicity along with antioxidant enzymes activities were evaluated in Wistar rats. The healthy adult rats were orally administered with 300 and 2000 mg/kg body weight of DFNM using a gastric needle and observed for 14 days. None of the animals showed any adverse effects/toxicity at the end of observation period. After two weeks of administration, blood was collected and subjected to haematological and biochemical analysis. Animals were sacrificed and gross necropsy was done on all animals. Liver was dissected; homogenized (10% homogenate) and rate of formation of lipid peroxides were evaluated. In addition, the concentration of reduced glutathione and the activity of vital antioxidant enzymes like glutathione reductase, glutathione peroxidase and superoxide dismutase was determined. The result of the study indicates that even at 2000 mg/kg body weight, DFNM was non-toxic. It was also observed that there was a slight fluctuation in the level of antioxidant enzymes activity, lipid peroxidation, haematological and biochemical parameters but it was not significant. Hence, it can be concluded that the in-house synthesized DFNM was non-toxic and shows no lethal effects when orally exposed to rats.en_US
dc.identifier.citationJ Allergy Ther. 2014;5(2):166-en_US
dc.identifier.urihttp://dx.doi.org/10.1038/srep0596810.4172/2155-6121.1000166
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/2308
dc.publisherJ Allergy Theren_US
dc.titleToxicity evaluation of dextran coated ferrite nanomaterials after acute oral exposure to Wistar rats.en_US
dc.typeArticleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Journal Articles