Coexistence of idiopathic generalized epilepsy among surgically treated patients with drug-resistant temporal lobe epilepsy

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dc.contributorRadhakrishnan, Ashalatha
dc.contributorMenon, Ramshekar N.
dc.contributorRadhakrishnan, Kurupath
dc.date.accessioned2012-12-04T11:43:42Z
dc.date.available2012-12-04T11:43:42Z
dc.date.issued2011
dc.description.abstractIntroduction: Failure to identify the association antiepileptic drug (AED)-resistant temporal lobe epilepsy (TLE) with idiopathic generalized epilepsy (IGE) can interfere with decision for anterior temporal lobectomy (ATL) and prediction of post-ATL seizure outcome.Methods: Out of the 664 consecutive patients who underwent ATL between March 1995 and December 2007, 12 (1.8%) had coexisting IGE. The decision for ATL was made after a thorough discussion in the multidisciplinary patient management conference based upon the concordance between the clinical, electroencephalographic and magnetic resonance imaging data. All of them underwent epilepsy surgery for AED-resistant TLE.Results: In seven of the 12 patients, IGE was not identified until post-ATL. During a median follow-up period of 8.5 years, 8 of our 12 patients were seizure-free; the remaining 4 patients only had infrequent myoclonus. In two them, AEDs were discontinued; others were on montherapy for IGE.Conclusions: Our study highlights the rare association of IGE with TLE, the most common AED-resistant focal epilepsy syndrome. As the seizure outcome following ATL is similar in AED-resistant TLE patients with and without IGE, their co-existence is not a contraindication for ATL. Future studies should explore the molecular genetic basis of the rare association between these two epilepsy syndromes. (C) 2011 Elsevier B.V. All rights reserved.
dc.identifier.citationEPILEPSY RESEARCH. 96; 40910; 151-157en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.eplepsyres.2011.05.016
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/pubmed/21665438
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/277
dc.publisherEPILEPSY RESEARCH
dc.subjectNeurology
dc.titleCoexistence of idiopathic generalized epilepsy among surgically treated patients with drug-resistant temporal lobe epilepsy
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