Phthalyl Chitosan-Poly(ethylene oxide) Semi-Interpenetrating Polymer Network Microparticles for Oral Protein Delivery: An In Vitro Characterization

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dc.contributor.authorRekha, MR
dc.contributor.authorSharma, CP
dc.date.accessioned2017-03-10T03:28:03Z
dc.date.available2017-03-10T03:28:03Z
dc.date.issued2008
dc.description.abstractPhthalyl chitosan (PC) was synthesized and phthalyl chitosan-poly(ethylene oxide) (PCP) semi-interpenetrating network microparticles were developed by ionic crosslinking with sodium tripolyphosphate. The characterization of PCP particles was done, and these particles were compared with PC and native chitosan (NC) microparticles. The PCP particle size was around 1.3 mu m with a potential of about -28.6 +/- 12.6 mV and an insulin loading efficiency of 89.6%. The release studies were done at pH 1.2 and 7.4, which indicated a minimal release at pH 1.2 compared to that at pH 7.4. The degree of swelling was observed to be higher in PCP than in PC or NC particles. The in vitro mucin-binding capacity and the intestinal mucoadhesiveness of the particles were evaluated. The PCP particles were highly mucoadhesive, and correspondingly, the mucin-binding capacity was lower for these particles; this is necessary for any matrix to be a successful mucoadhesive. These results suggest the usefulness of these particles as a potential candidate for oral insulin-delivery systems. (C) 2008 Wiley Periodicals, Inc. J Appl Polym Sci 110: 2787-2795, 2008
dc.identifier.citation110 ,5;2787-2795en_US
dc.identifier.uri10.1002/app.28832
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/10231
dc.publisherJOURNAL OF APPLIED POLYMER SCIENCE
dc.subjectPolymer Science
dc.titlePhthalyl Chitosan-Poly(ethylene oxide) Semi-Interpenetrating Polymer Network Microparticles for Oral Protein Delivery: An In Vitro Characterization
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