Surgery for "Long-term epilepsy associated tumors (LEATs)": Seizure outcome and its predictors

Simple item page
dc.contributor.authorRadhakrishnan, A
dc.contributor.authorAbraham, M
dc.contributor.authorVilanilam, G
dc.contributor.authorMenon, R
dc.contributor.authorMenon, D
dc.contributor.authorKumar, H
dc.contributor.authorCherian, A
dc.contributor.authorRadhakrishnan, N
dc.contributor.authorKesavadas, C
dc.contributor.authorThomas, B
dc.contributor.authorSarma, SP
dc.contributor.authorThomas, SV
dc.date.accessioned2016-03-23T06:51:30Z
dc.date.available2016-03-23T06:51:30Z
dc.date.issued2016-02
dc.description.abstractObjectives: “Long-term epilepsy associated tumors (LEATs)” by definition are tumors primarily causing drug-resistant seizures for two years or more. They include low-grade glial and glioneuronal tumors with normal life expectancy. We studied a large cohort of patients with LEATs who underwent surgery through our epilepsy program. Patients & methods: From 1998–2011, 105 patients with LEATs underwent surgery in our center. We utilized their data archived in a prospective registry to evaluate their electro-clinical-imaging characteristics affecting the long-term seizure outcome. Results: Of 105patients (age 3–50 years),meanage at surgery was 20 years andmeanpre-surgicalduration of epilepsy was 10.9 years. 66 (62.8%) had secondary generalized seizures. 82 had temporal tumors, 23 had extra temporal (13 frontal, 3 parietal, 2 occipital and 5 multilobar lesions) and four had associated hippocampal sclerosis. The interictal discharges and ictal onset were concordant to the lesion in 82 (78%) and 98 (93%) patients respectively. Lesionectomy and/or adjoining corticectomy or temporal lobectomy was done. Ganglioglioma was the most dominant pathological substrate in 61 (58%). During a mean follow-up of 7.5 years (range 3–16 years), 78/105 (74.2%) were seizure-free and 45 (57.4%) were totally off drugs. Secondary generalized seizures (p-0.02), temporal location of tumor (p-0.008) and spikes in third month post-operative EEG (p-0.03) caused unfavorable seizure outcome. A pre-surgical duration of epilepsy of more than 6.6 years caused less than optimal surgical outcome Conclusions: Early surgery should be considered a priority in LEATs. Presence of secondary generalized seizures is the single most important predictor of a poor seizure outcomeen_US
dc.identifier.citationRadhakrishnan A, Abraham M, Vilanilam G, Menon R, Menon D, Kumar H, Cherian A, Radhakrishnan N, Kesavadas C, Thomas B, Sarma SP, Thomas SV. Surgery for "Long-term epilepsy associated tumors (LEATs)": Seizure outcome and its predictors. Clin Neurol Neurosurg. 2016;141:98-105en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.clineuro.2015.12.020
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/2710
dc.publisherClin Neurol Neurosurgen_US
dc.subjectLEATs Seizure outcome Resective surgeryen_US
dc.titleSurgery for "Long-term epilepsy associated tumors (LEATs)": Seizure outcome and its predictorsen_US
dc.typeArticleen_US
Files
Collections
Journal Articles