Biocompatibility property of 100% strontium-substituted SiO2-Al2O3-P2O5- CaO-CaF2 glass ceramics over 26 weeks implantation in rabbit model: Histology and micro-Computed Tomography analysis.
No Thumbnail Available
Date
2014-08
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of Biomedical Materials Research Part B: Applied Biomaterials.
Abstract
One of the desired properties for any new biomaterial
composition is its long-term stability in a suitable animal
model and such property cannot be appropriately assessed
by performing short-term implantation studies. While
hydroxyapatite (HA) or bioglass coated metallic biomaterials
are being investigated for in vivo biocompatibility properties,
such study is not extensively being pursued for bulk glass
ceramics. In view of their inherent brittle nature, the implant
stability as well as impact of long-term release of metallic
ions on bone regeneration have been a major concern. In
this perspective, the present article reports the results of the
in vivo implantation experiments carried out using 100%
strontium (Sr)-substituted glass ceramics with the nominal
composition of 4.5 SiO2–3Al2O3–1.5P2O5–3SrO–2SrF2 for 26
weeks in cylindrical bone defects in rabbit model. The combination
of histological and micro-computed tomography analysis
provided a qualitative and quantitative understanding of
the bone regeneration around the glass ceramic implants in
comparison to the highly bioactive HA bioglass implants
(control). The sequential polychrome labeling of bone during
in vivo osseointegration using three fluorochromes followed
by fluorescence microscopy observation confirmed homogeneous
bone formation around the test implants. The results
of the present study unequivocally confirm the long-term
implant stability as well as osteoconductive property of 100%
Sr-substituted glass ceramics, which is comparable to that of
a known bioactive implant, that is, HA-based bioglass.
Description
Keywords
in vivo, micro-CT, orthopedic, strontium, glass ceramics, implant stability
Citation
Journal of Biomedical Materials Research Part B: Applied Biomaterials. 2014