Gender influence on selection and outcome of deep brain stimulation for Parkinson’s disease

Simple item page
dc.contributor.authorChandran, S
dc.contributor.authorSyam, K
dc.contributor.authorRao, RM
dc.contributor.authorSarma, SG
dc.contributor.authorSarma, PS
dc.contributor.authorKishore, A
dc.date.accessioned2015-01-16T02:43:43Z
dc.date.available2015-01-16T02:43:43Z
dc.date.issued2014-12
dc.description.abstractBACKGROUND: Gender differences exist in Parkinson's disease (PD), both in clinical manifestations and response to medical treatment. We investigated whether gender differences occur in the clinical characteristics of patients selected for bilateral subthalamic nucleus deep brain stimulation (STN DBS) or in the outcome when resource limits influence treatment choices made by patients. MATERIALS AND METHODS: Fifty-one consecutive patients were evaluated 1 month before, and 12 months after bilateral STN DBS. All patients were rated using Unified Parkinson's Disease Rating Scale, Parkinson's Disease Quality of Life (PDQL) Scale, Addenbrooke's Cognitive Examination and Beck Depression Inventory. RESULTS: Pre-operative characteristics did not differ between the genders except for lower doses of drugs (P = 0.03), worse emotional scores in PDQL (P = 0.01) and worse depression (P = 0.03) in women. There was no gender difference in the surgical outcome, except a lesser reduction of dopaminergic drugs in women. Depression and quality of life (QOL) improved equally well in women and men. CONCLUSION: Bilateral STN DBS is equally efficacious in both genders as a treatment for motor complications of PD and for improving QOL. Women are likely to be undertreated because of more severe dyskinesia and may experience less emotional well-being, and could therefore potentially benefit from earlier surgical treatment.en_US
dc.identifier.citationChandran S1, Krishnan S1, Rao RM1, Sarma SG1, Sarma PS2, Kishore A."Gender influence on selection and outcome of deep brain stimulation for Parkinson’s disease",Annals of Indian Academy of Neurology. 2014;17(1):66-70.en_US
dc.identifier.urihttp://dx.doi.org/10.4103/0972-2327.128557
dc.identifier.urihttps://dspace.sctimst.ac.in/handle/123456789/2330
dc.publisherAnnals of Indian Academy of Neurologyen_US
dc.subjectDeep brain stimulation; Parkinson's disease; gender differencesen_US
dc.titleGender influence on selection and outcome of deep brain stimulation for Parkinson’s diseaseen_US
dc.typeArticleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Journal Articles