Immunohistochemical demonstration of mycobacterial antigens in intracranial tuberculoma.

dc.contributor	Radhakrishnan, V V
dc.contributor	Mathai, A
dc.contributor	Radhakrishnan, N S
dc.contributor	Rout, D
dc.contributor	Sehgal, S
dc.date.accessioned	2012-12-04T11:44:19Z
dc.date.available	2012-12-04T11:44:19Z
dc.date.issued	1991
dc.description.abstract	Mycobacterial antigens have been demonstrated immunohistochemically in the paraffin sections of 10 intracranial tuberculous granulomas and the results were compared with the detection of acid fast bacilli by conventional Ziehl-Neelsen method. In none of the 10 specimens, acid fast bacilli were demonstrated while mycobacterial antigens were characterised as diffusely staining granular brownish-pink material within the cytoplasm of giant cells and macrophages. In 14 specimens of granulomatous lesions due to non-tuberculous aetiology, immunohistochemical stains were negative for mycobacterial antigen. Thus demonstration of mycobacterial antigen will be not only useful in establishing mycobacterial aetiology of a caseating intracranial granuloma but also can be used as an alternative method to the conventional Ziehl-Neelsen method.
dc.identifier.citation	Indian journal of experimental biology. 29; 7; 641-4	en_US
dc.identifier.uri	https://dspace.sctimst.ac.in/handle/123456789/608
dc.publisher	Indian journal of experimental biology
dc.subject	Pathology
dc.title	Immunohistochemical demonstration of mycobacterial antigens in intracranial tuberculoma.